A5026399800- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Artificial Intelligence in Healthcare
- Dementia and Cognitive Impairment Research
- Fuzzy Logic and Control Systems
- Data Mining Algorithms and Applications
- Neural Networks and Applications
- Parkinson's Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Cognitive Abilities and Testing
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Machine Learning in Bioinformatics
- Cerebrovascular and Carotid Artery Diseases
- Gene expression and cancer classification
- Genetics and Neurodevelopmental Disorders
- Digital Imaging for Blood Diseases
- Genomics and Rare Diseases
- Liver Disease Diagnosis and Treatment
- Plant Genetic and Mutation Studies
- Data Mining and Machine Learning Applications
- Multimedia Learning Systems
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
Lund University
2020-2024
Malmö University
2024
Skåne University Hospital
2022-2023
University of California, San Francisco
2023
University of Chicago
2018
Karunya University
2010-2018
Abstract Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer’s disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of AD pathology living humans. We found 127 differentially abundant proteins (DAPs) across spectrum. The strongest Aβ-related were mainly expressed glial cells included SMOC1 ITGAM. A dozen...
Abstract The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have limited sensitivity until most dopaminergic neurons are lost. Here we show that cerebrospinal fluid levels DOPA decarboxylase (DDC) (also known as aromatic l -amino acid decarboxylase) can accurately identify patients with Lewy body disease (LBD) (area under the curve (AUC) = 0.89; P FDR 2.6 × 10 −13 ) and associated worse cognitive performance ( < 0.05). We also found DDC detect...
Article12 December 2022Open Access Source DataTransparent process The genetic regulation of protein expression in cerebrospinal fluid Oskar Hansson Corresponding Author [email protected] orcid.org/0000-0001-8467-7286 Clinical Memory Research Unit, Faculty Medicine, Lund University, Lund, Sweden Clinic, Skåne University Hospital, Contribution: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Methodology, Project administration, Writing - review & editing Search...
The BIN1 rs744373 single nucleotide polymorphism (SNP) is a key genetic risk locus for Alzheimer's disease (AD) associated with tau pathology. Because typically accumulates in response to amyloid beta (Aβ), we tested whether accelerates Aβ-related accumulation.We included two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI], n = 153; Biomarkers Identifying Neurodegenerative Disorders Early and Reliably [BioFINDER], 63) longitudinal 18 F-Flortaucipir positron emission tomography...
Type 2 diabetes and dementia are associated, but it is unclear whether the two diseases have common genetic risk markers that could partly explain their association. It also association between of a causal nature. Furthermore, few studies on validated end-points with high diagnostic precision. We tested associations polygenic scores for type diabetes, fasting glucose, insulin haemoglobin A
Abstract Disease-specific fluid biomarkers are in demand for parkinsonian syndromes (PS). Corticotropin-releasing hormone (CRH) was proposed as a biomarker Lewy body disease. As such, this project aimed to confirm CRH potential different PS. and misfolded α-synuclein (αSyn) were measured CSF. The primary cohort included disease patients (i.e. Parkinson’s or dementia with bodies, n = 77), atypical PS (n 37) non-parkinsonian neurodegenerative diseases 164), well controls 354). A replication...
Abnormal metabolism of β-amyloid (Aβ) and soluble phosphorylated tau (P-tau), as well neurodegeneration, are key components Alzheimer disease (AD), but it is unclear how these different processes related to genetic risk factors for AD.In the Swedish BioFINDER study, we tested associations between a priori defined polygenic scores (PRSs) AD (excluding single-nucleotide polymorphism [SNP] within APOE region in main analysis) biomarkers CSF (total [T-tau] P-tau181; Aβ1-38, Aβ1-40, Aβ1-42,...
Abstract Cognitive decline in early-stage Alzheimer’s disease (AD) may depend on genetic variability. In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence, and educational attainment) to predict longitudinal cognitive change (measured by mini-mental state examination (MMSE) [primary outcome] other tests) over a mean of 4.2 years. We included 260 β-amyloid (Aβ) negative cognitively unimpaired (CU) individuals, 121 Aβ-positive CU (preclinical AD), 50 Aβ-negative...
Type II diabetes is a chronic condition that affects the way our body metabolizes sugar. The body's important source of fuel now becoming disease all over world. It very necessary to identify new potential targets for drugs which not only control but also can treat it. Support vector machines are classifier has make classification discriminatory genes and non-discriminatory genes. SVMRFE modification SVM ranks based on their power eliminate involved in causing disease. A gene regulatory...
Rheumatoid Arthritis (RA) is a multifactorial auto-immune disease of unknown etiology. Activation innate immune systems including B and T lymphocytes the earliest step in RA pathogenesis. Bruton's Tyrosine Kinase (BTK) plays crucial role activation cells it being reported as one key drug targets for RA. Available therapeutic kinase inhibitors are associated with various side-effects, none them satisfies ultimate goal treatment options. Concurrently, several herbal compounds have been...
<h3>Objectives:</h3> There is considerable heterogeneity in the association between increasing amyloid β (Aβ) pathology and early cognitive dysfunction preclinical Alzheimer's disease (AD). At this stage, some individuals show no signs of dysfunction, while others clear decline. The factors explaining are particularly important for understanding progression AD but remain largely unknown. In study, we examine an array genetic variants that may influence relationships among Aβ, brain...
Gout is a painful arthritis that paralyzes human being form period of time; it’s global disease emerging due to life-style change. Many drugs are available but they fail suppress the inflammation and pain quickly lack knowledge about molecules which indirectly interact with each other take part in pathogenesis gout. Relationship between molecular interaction network topology their function has been one major challenges developing novel therapy; hence analysis provides an effective way...
Abstract Background The BIN1 rs744373 SNP is a key risk locus for Alzheimer’s disease (AD). Cross‐sectional studies showed to be associated with higher tau pathology, i.e. AD pathological hallmark that Aβ. Whether carriage of the accelerates association between Ab and rate accumulation unclear. Here, we examined whether risk‐allele‐carriers show faster Aβ‐related thus cognitive decline. Method We included two independent samples (ADNI, n=153; BioFINDER, n=63) characterized longitudinal 18...
Abstract Background Cerebral small vessel disease (SVD) is a cerebrovascular condition associated with age that contributes to dementia, stroke, and other neurological disorders. White matter lesions (WML), microbleeds, infarcts are hallmarks of SVD, but their molecular mechanisms poorly understood. The aim this study was investigate the CSF proteomic changes underlying pathogenesis SVD subtypes. Method We analysed samples controls patients (295 WML, 149 microbleeds 64 infarcts, total 894...
The pathophysiology underlying various manifestations of cerebral small vessel disease (cSVD) remains obscure. Using cerebrospinal fluid proximity extension assays and co-expression network analysis 2,943 proteins, we found common distinct proteomic signatures between white matter lesions (WML), microbleeds infarcts measured in 856 living patients, validated WML-associated proteins three additional datasets. Proteins indicative extracellular matrix dysregulation vascular remodeling,...
Designing of fuzzy inference systemFuzzy is a method that interprets the values in input and based on user defined Rules, assigns to output.For developing diagnosing tool for Eosinophilia, data required;