A5062268833- Muscle Physiology and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiomyopathy and Myosin Studies
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Tissue Engineering and Regenerative Medicine
- American Literature and Culture
- Poetry Analysis and Criticism
- American and British Literature Analysis
- Muscle metabolism and nutrition
- Virus-based gene therapy research
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
The Ohio State University
2021
Nationwide Children's Hospital
2019
rAAVrh74.MCK.GALGT2 is a surrogate gene therapy that inhibits muscular dystrophy in multiple animal models. Here, we report on dose-response study of functional muscle GALGT2 expression as well toxicity and biodistribution studies after systemic intravenous (i.v.) delivery rAAVrh74.MCK.GALGT2. A dose 4.3 × 1014vg/kg (measured with linear DNA standard) resulted GALGT2-induced glycosylation the majority skeletal myofibers throughout body almost all cardiomyocytes, while several lower doses...
We have examined the effects of intravenous (IV) delivery rAAVrh74.MHCK7. GALGT2 in golden retriever muscular dystrophy (GRMD) model Duchenne Muscular Dystrophy (DMD). After baseline testing, GRMD dogs were treated at 3 months age and reassessed 6 months. This 3–6 month range is a period rapid disease progression, thus offering relatively short window to establish treatment efficacy. Measures analyzed included muscle AAV transduction, transgene expression, -induced glycosylation, pathology,...
The majority of maternal deaths occur in the postpartum period. We sought to compare readmission by race and ethnicity better understand whether there are disparities health period as indicated hospital.This study aimed use state-wide Maryland data identify rates ethnicity, well major risk factors, indications, timing readmission.In this retrospective (2016-2019), childbirth hospitalizations for patients childbearing age were identified from State Inpatient Database, Healthcare Cost...
Abstract This article explores the palimpsestic nature of Steinbeck's classic novel The Grapes Wrath by comparing it to modern multimedia play House/Divided. Though was written before invention literary device palimpsest, interweaving different prose styles and subject matter in novel's intercalary chapters substantiates an organic form contemporary device. By corresponding characteristics defining play's techniques, this essay discusses how both works utilize palimpsest achieve same ends:...
INTRODUCTION: In Maryland, 81% of pregnancy-related deaths occurred in the postpartum period. We sought to compare readmission by race and ethnicity better understand disparities maternal mortality. METHODS: this retrospective study (2016–2019), childbirth hospitalizations from Maryland State Inpatient Database for childbearing age patients were analyzed. Indication was described. Multivariable logistic regression models employed determine differences readmissions, adjusting obstetric...