SUMMARY Blood gases (PO2, PCO2, pH), oxygen content, hematocrit and hemoglobin concentration were measured during rest-associated apneas of nine juvenile northern elephant seals. In conjunction with blood volume determinations, these data used to determine total stores, the rate magnitude O2 depletion, contribution store apneic metabolic rate, degree hypoxemia that occurs breath-holds. Mean body mass was 66±9.7 kg (± s.d.); 196±20 ml kg–1; 23.5±1.5 g dl–1. Rest ranged in duration from 3.1...

In microvascular tissue transfers, it is essential postoperatively to follow-up on the perfusion of transferred flap because risk anastomotic failure. The diagnosis pedicle obstruction usually made by clinical observation, but some techniques have been reported as more reliable than observation in detecting authors used microdialysis (MD), a method developed assess situ metabolism, 80 consecutive flaps from October, 2001 2003. Of 78 with postoperative data, 58 were uneventful clinically and...

Deep sedation is often necessary after major reconstructive plastic surgery in the face and neck regions to prevent sudden spontaneous movements capable of inflicting mechanical injury transplanted musculocutaneous flap(s). An adequate positioning may help optimize oxygenation perfusion tissues. We hypothesized that dexmedetomidine, a central alpha2-agonist otherwise potentially ideal postoperative sedative drug, induce vasoconstriction denervated flaps, thus increase risk tissue...

Few studies have examined the cost-effectiveness of microsurgery, and little is known about flap monitoring. We studied costs related to microsurgery during 2004 2006 in Kuopio University Hospital. A total 99 patients were reconstructed with 109 flaps. Primary success was achieved 64% cases. Reoperation for anastomosis conducted 25% other surgical complications 27%. The intended result 94% mean cost hospital care 20,000 euro head neck cancer surgery, 15,500 defects lower extremities, 9200...

Infection of sternotomy wound is a rare potentially fatal complication because the risk for deep sternal infection. Current treatment comprises antibiotics, debridement, negative pressure therapy and sometimes transposition muscle or omental flaps to fill anterior mediastinal dead space.The management 60 consecutive infections reviewed. The one stage was mostly chosen. In 5 patients after used before flap reconstruction. Fifty-seven were rewired 3 had sternectomy. choice based mainly on...

Microvascular flap surgery is a common technique in reconstructive surgery. The wide indications and variable patients provide challenge also for anesthesiologist. Both hypotension hypoperfusion can be harmful to the flap. Hypotensive are treated with fluid resuscitation vasopressors (e.g., norepinephrine), if needed. As vasoconstrictors, might impair microvascular perfusion. In this experimental pig model we studied effect of sevoflurane-induced on perfusion superiorly pedicled rectus...

Introduction. Negative pressure wound therapy (NPWT) has widely become the first-line option in treatment of deep sternal infections. After several positive reports comparison with conventional treatment, very recent studies comparing NPWT early reconstruction have favored latter. Our aim was to evaluate effectiveness and safety flap reconstruction. Materials methods. We concluded a retrospective analysis 125 patients infection treated single institution between years 2006 2018. became our...

Background and objective: Deep sternal wound infection is a feared complication of open-heart surgery. Negative pressure therapy has gained an important role in the treatment deep infection. Incisional negative been introduced as method to prevent complications after sternotomy, lately, flap reconstructions We aimed study if incisional with PICO™ had similar beneficial effect described earlier competing commercial devices. Methods: This included 82 patients treated pectoralis major muscle...

Aim: The aim was to study the impact of nationwide clinical practice guidelines for soft tissue sarcomas (STS), introduced in 1994 and again 2005 North Savo, Finland.

Incisional negative pressure wound therapy has been described as an effective method to prevent infections after open heart surgery in several publications. However, most studies have examined relatively small patient groups, only a few were randomized, and some manufacturer-sponsorship. Most of the utilized Prevena; there are reports describing PICO incisional system. We conducted prospective cohort study involving propensity score-matched analysis evaluate effect coronary artery bypass...

There are multiple treatment strategies and flap options to cover defects after deep sternal wound infections other similar defects. The choice of is made according surgeons' preferences the size location defect. Our aim introduce a new option these kinds with an internal mammary artery perforator combined pectoralis major muscle mostly raised muscle-sparing technique.We treated 13 patients defect cardiothoracic operations this technique between 2010-2016. Ten had infection, two infection...

Background. Extracellular glycerol as detected by microdialysis has been used a surrogate marker for (ischemic) tissue damage and cellular membrane breakdown in the monitoring of free microvascular musculocutaneous flaps. One confounding factor ischemic cell is effect lipolysis associated release induced sympathetic signalling alone. We hypothesized that extracellular concentrations flap with innervation would be confounded intact per se compared to denervated flap. Clinical relevance...