A5101055198- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Protein Interaction Studies and Fluorescence Analysis
- Electrochemical Analysis and Applications
- Sulfur Compounds in Biology
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Enzyme-mediated dye degradation
- Porphyrin and Phthalocyanine Chemistry
- Chromatin Remodeling and Cancer
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Synthesis and Biological Evaluation
- DNA and Nucleic Acid Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chromium effects and bioremediation
- Pharmacological Effects and Assays
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Carbon Dioxide Capture Technologies
- Carbon and Quantum Dots Applications
The University of Texas MD Anderson Cancer Center
2024-2025
Jiangxi Agricultural University
2023-2024
University of Jinan
2008-2023
Changchun University of Chinese Medicine
2019
Chengdu Organic Chemicals (China)
2010-2013
Chinese Academy of Sciences
2010-2013
University of Chinese Academy of Sciences
2013
Sichuan Academy of Agricultural Sciences
2012
Chengdu Institute of Biology
2011-2012
Tang Du Hospital
2011
An efficient FeCl3-catalyzed stereoselective intramolecular tandem 1,5-hydride transfer/ring closure reaction was developed. The method allows for the formation of structurally diverse spirooxindole tetrahydroquinolines in high yields (up to 98%) with good excellent levels diastereoselectivity 99:1 dr). catalytic enantioselective variant this process also investigated preliminarily a chiral BINOL-derived phosphoric acid.
An efficient and stereoselective reaction between 3-isothiocyanato oxindoles isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles dispiro[imidazolidine-2-thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means a chiral auxiliary was explored. isomers are separable, products could be isolated as single diastereomers column chromatography. Further synthetic transformations the...
Hydrazine is widely used in industrial and agricultural production, but excessive hydrazine possesses a serious threat to human health environment. Here two new ratiometric fluorescence probes, DDP DDC, with the hydroxyl coumarin chalcone unit as sensing site are developed, which can achieve colorimetric recognition for good sensitivity, excellent selectivity, anti-interference. The calculated limits of detections 0.26 μM (DDC) 0.14 (DDP). response realized through adjustment donor receptor...
A simple catalyst system assembled from an enantiomerically pure diamine ligand and Ni(OAc)2 efficiently generates chiral metal enolates derived 3-substituted oxindoles bearing N-1 carbonyl group. The smoothly undergo diastereo- enantioselective conjugate addition to a wide range of nitroolefins under mild reaction conditions, furnishing 3,3-disubstituted oxindole products two vicinal quaternary/tertiary stereocenters in 74–95% yields 60:40 99:1 dr, 71–97% ee.
Abstract Cancer genomic studies have identified frequent alterations in genes encoding components of the SWI/SNF chromatin remodeling complex, including SMARCA4 and ARID1A. Importantly, clinical reports indicate that SMARCA4-mutant lung cancers respond poorly to immunotherapy dismal prognosis. Here, we corroborated findings by using immune-humanized, syngeneic, genetically engineered mouse models cancer harboring deficiency. Specifically, with loss showed decreased response anti-PD1...
Genomic studies have identified frequent mutations in subunits of the SWI/SNF (switch/sucrose non-fermenting) chromatin remodeling complex including SMARCA4 and ARID1A non-small cell lung cancer (NSCLC). Genetic evidence indicates that paralog SMARCA2 is synthetic lethal to suggesting a valuable therapeutic target. However, discovery selective inhibitors has been challenging. Here, we utilized structure-activity relationship (SAR) develop YD23, potent proteolysis targeting chimera (PROTAC)...
Abstract It is well known that microRNAs (miRNAs) are crucial regulatory factors in tumorigenesis, as tumor suppressors or cancer‐promoting factors. However, the study of endometrial carcinoma relevance miR‐522 rare, indicating an undefined molecular mechanism for its role. Therefore, we performed this to examine role on biological behaviors carcinoma. In work, found was highly expressed and negatively regulated monoamine oxidase B (MAOB) expression. They also have opposite effect prognosis...
ABSTRACT Cancer genomic studies have identified frequent mutations in subunits of the SWI/SNF chromatin remodeling complex including SMARCA4 non-small cell lung cancer with a frequency up to 33% advanced stage disease, making it most frequently mutated cancer. We and others SMARCA2 be synthetic lethal SMARCA4, indicating is high value therapeutic target. Here, we disclose discovery characterization potent, selective orally bioavailable Cereblon-based PROTACs. Biochemically, YDR1 YD54 are...
ABSTRACT Based on the inhibition effect of transferrin (Tf) reaction luminol–hydrogen peroxide (H 2 O ) chemiluminescence (CL) system, catalysed by meso‐tetra‐(3‐methoxyl‐4‐hydroxyl) phenyl manganese porphyrin (MnP) as a mimetic enzyme peroxides, sensitive flow‐injection CL method has been developed for determination Tf in an alkaline medium. The was carefully investigated examining variations conditions. Under optimum conditions, linear range 0.04–20.0 μg/mL and detection limit 1.62 ng/mL....