About
Contact & Profiles
A5072271953
Research Areas
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Pharmaceutical studies and practices
Albireo (Sweden)
2023
Cholestasis is characterized by intrahepatic accumulation of bile constituents, including acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in reabsorption and signaling ileum, ducts, kidneys. Our aim was to investigate the pharmacokinetics pharmacological activity A3907, oral systemically available ASBT inhibitor experimental mouse models cholestasis. In addition, tolerability, pharmacokinetics, pharmacodynamics A3907 were...
10.1097/hep.0000000000000376
article
EN
cc-by-nc-nd
Hepatology
2023-03-31
10.1016/s0168-8278(23)00528-7
article
EN
Journal of Hepatology
2023-06-01
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