Mirabel E. Dafinone

ORCID: 0009-0000-6273-7954
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About
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Research Areas
  • Wound Healing and Treatments
  • Cancer and Skin Lesions
  • Hedgehog Signaling Pathway Studies
  • Nonmelanoma Skin Cancer Studies
  • Diabetic Foot Ulcer Assessment and Management
  • Pressure Ulcer Prevention and Management
  • Cultural Competency in Health Care
  • Empathy and Medical Education
  • Antimicrobial agents and applications
  • Bacterial biofilms and quorum sensing
  • Biochemical Analysis and Sensing Techniques
  • Cancer-related molecular mechanisms research
  • Peripheral Artery Disease Management
  • Global Health Workforce Issues
  • MicroRNA in disease regulation

VA Northern California Health Care System
2024

University of California, Davis
2024

University of Nevada, Reno
2023-2024

Abstract Background/Aim Diabetes has substantive co‐occurrence with disorders of gut‐brain interactions (DGBIs). The pathophysiological and molecular mechanisms linking diabetes DGBIs are unclear. MicroRNAs (miRNAs) key regulators gut dysmotility. We investigated whether impaired barrier function is regulated by a miRNA, miR‐10b‐5p, Methods created new mouse line using the Mb3Cas12a/Mb3Cpf1 endonuclease to delete mir‐10b globally. Loss studies in knockout (KO) mice were conducted...

10.1002/ueg2.12463 article EN cc-by-nc-nd United European Gastroenterology Journal 2023-09-18

Diabetic foot ulcers are a common complication in diabetes, leading to high amputation risk and significant healthcare costs. Given topical timolol's emergence as potential wound-healing agent, our study explored its impact on epidermal integrity. This was post-hoc analysis conducted part of randomized controlled trial at the Veterans Affairs Northern California Health Care System. Twenty patients who had diabetic healed original trial, 10 timolol arm placebo arm, were enrolled study. The...

10.1159/000545357 article EN Skin Pharmacology and Physiology 2025-03-28

The current healthcare system disproportionately affects vulnerable populations, leading to disparities in health outcomes. As a result, medical schools need equip future physicians with the tools identify and address disparities. University of Nevada, Reno School Medicine implemented Scholarly Concentration Medical Social Justice (SCiMSJ) program this issue. Three students joined pioneered project equitable vaccine distribution within local Hispanic/Latinx community. After identifying...

10.1080/10872981.2023.2241169 article EN cc-by Medical Education Online 2023-07-27
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