A5040443483- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Endometrial and Cervical Cancer Treatments
- Medical Imaging and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Prostate Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Colorectal and Anal Carcinomas
- Renal cell carcinoma treatment
University of Kentucky
2017-2025
University of Virginia
2024-2025
Max Planck Institute for Multidisciplinary Sciences
2025
Tissue Dynamics (Israel)
2025
Center for Cancer Research
2006-2023
Markey Cancer Center
2019-2023
UPMC Hillman Cancer Center
2011-2021
University of Pittsburgh
2011-2015
University of Pittsburgh Medical Center
2014
Shadyside Hospital
2014
Background: We determined factors associated with morbidity and outcomes of a series non-small cell lung cancer (NSCLC) patients treated dose escalated chemoradiotherapy at the University Pittsburgh Lung Cancer Program. Methods Materials: The records 170 stage III NSCLC definitive intent were retrospectively reviewed. All received 4D-CT simulation scan had respiratory gating if tumor movement exceeded 5 mm. Overall survival (OS), locoregional control (LRC), freedom from distant metastasis...
Radiation treatment is considered an effective and the most common option for prostate cancer. The planning process requires accurate precise segmentation of organs at risk (OARs), which laborious time-consuming when contoured manually. Artificial intelligence (AI)-based auto-segmentation has potential to significantly accelerate radiation therapy process; however, accuracy needs be validated before its full clinical adoption.A commercial AI-based contouring model was trained provide...
Nitric oxide (NO(*)), an important signaling molecule and a component of inflammatory response, is involved in tumorigenesis. However, the quantity NO(*) cellular microenvironment influences role tumor development. We used genetic strategy to test hypothesis that with enhanced level accelerates spontaneous C. parvum-induced inflammation increased synthase-2 (NOS2) expression coincided accelerated development, mostly lymphomas, p53-/-NOS2+/+ C57BL6 mice when compared controls (P = 0.001)....
Contouring error is one of the top failure modes in radiation treatment. Multiple efforts have been made to develop tools automatically detect segmentation errors. Deep learning-based auto-segmentation (DLAS) has used as a baseline for flagging manual errors, but those are limited using only or two contour comparison metrics.
To determine the distributions of published α/β values measured in vitro and resulting uncertainties equivalent dose 2 Gy fractions (EQD2) when applied to high-dose-rate brachytherapy (HDR-BT) for cervical cancer. An analysis 98 from 31 papers was conducted, spanning 23 cancer cell lines. Values were further divided into squamous carcinoma adenocarcinoma histologies. Probability fit histograms using bootstrapped Kolmogorov-Smirnov goodness-of-fit test. Both average most probable determined....
Deep convolutional neural network (DCNN) has shown great success in various medical image segmentation tasks, including organ-at-risk (OAR) from computed tomography (CT) images. However, most studies use the dataset same source(s) for training and testing so that ability of a trained DCNN to generalize different is not well studied, as strategy address issue performance drop on dataset. In this study we investigated well-trained model public thoracic OAR local explored systematic differences...
Abstract Stereotactic body radiotherapy (SBRT) of lung tumors via the ring‐mounted Halcyon Linac, a fast kilovoltage cone beam CT‐guided treatment with coplanar geometry, single energy 6MV flattening filter free (FFF) and volumetric modulated arc therapy (VMAT) is fast, safe, feasible modality for selected cancer patients. Four‐dimensional (4D) CT‐based plans were generated using advanced AcurosXB algorithm heterogeneity corrections an SBRT board couch insert. VMAT‐SBRT stacked staggered...
This paper demonstrates the clinical feasibility and efficacy of HyperArc VMAT treatments for locally recurrent, advanced, or previously irradiated head neck cancers treated with stereotactic radiotherapy (SRT).First, an anthropomorphic SRS phantom from MD Anderson's IROC credentialing laboratory containing a 1.9 cm diameter spherical target, including in vivo dosimetry system, was imaged, planned, (25 Gy 1 fraction) using 6 MV flattening filter free (FFF) beam. Second, RANDO (35 5...
Microcanonical unimolecular rate theory is applied to Shirhatti and Wodtke's recent supersonic molecular beam experiments examining the activated dissociative chemisorption of HCl on Au(111). A precursor mediated microcanonical trapping (PMMT) model (where surface vibrates rotations, vibration, translation directed along normal are treated as active degrees freedom) gave sticking coefficient predictions that several orders magnitude higher than experimental values but in good accord with...
Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to crosslinking agents. Clinically, FA associated with high risk for marrow failure, leukemia head neck squamous cell carcinoma (HNSCC). Radiosensitivity in patients compromises the use of total-body irradiation hematopoietic stem transplantation radiation therapy HNSCC. A radioprotector surrounding tissue would therefore be very valuable during radiotherapy Clonogenic survival curves...
Purpose: To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator.Materials and methods: Murine hematopoietic progenitor 32D cl 3 cells were incubated in 1, 10, or 100 μM CBZ 1 h before immediately after 0–8 Gy irradiation assayed for clonogenic survival. Autophagy was by immunoblot microtubule-associated protein light chain (LC3). In vivo radioprotection mitigation determined with C57BL/6NTac mice.Results: treatment at 10 prior to increased radioresistance (the...
Glioblastoma multiforme (GBM) carries a poor prognosis with high recurrence rates. Salvage stereotactic radiosurgery (SRS) may be an effective treatment option.We retrospectively reviewed 34 patients (41 lesions) treated salvage SRS for recurrent GBM between 2004 and 2012. Initial surgical treatments were gross total resection (58%), subtotal (STR) (24%), biopsy (18%). All prior radiation therapy. Recurrent disease was median dose fractions of 23.4 Gy (range, 12-30) 3 1-3), respectively. Cox...
Abstract In lung tumors, the p53 tumor suppressor gene is commonly mutated with a characteristic mutation spectrum. The amount of and alterations in plasma DNA, such as mutations p53, were associated several cancers. Few studies used quantitative methods high sensitivity. Previously, we observed noncancerous tissue that differed from those tumors using highly sensitive load assay. Based on our observation an increased nontumorous smokers, hypothesized DNA may contain mutant indicative...
Purpose: The aim is to provide a practical approach the planning technique and evaluation of plan quality for multi-lesion, single-isocenter stereotactic ablative radiotherapy (SABR) lung. Methods Materials: Eleven patients with 2 or more lung lesions underwent VMAT radiosurgery IMRS. All plans were normalized target maximum dose. For each plan, all targets treated same Plan conformity dose gradient maximized control tuning structures surrounding targets. comparison, multi-isocenter...
Introduction: A growing body of preclinical data suggests that statins may exert potent antitumor effects, yet the interactions these medications with standard therapies and clinical outcomes in this population is less clear. We assessed impact statin use on patients advanced-stage pancreatic adenocarcinoma undergoing various treatments. Materials Methods: After institutional review board approval, we conducted a retrospective-cohort study consisting 303 newly diagnosed to determine...
To demonstrate the plan quality and delivery efficiency of volumetric-modulated arc therapy (VMAT) with Halcyon Linac ring system (RDS) in treatment single-isocenter/two-lesion lung stereotactic body radiation (SBRT).Sixteen previously treated non-coplanar VMAT SBRT plans delivered SBRT-dedicated C-arm TrueBeam were selected. Prescribed dose was 50 Gy to each lesion over five fractions every other day AcurosXB algorithm as final calculation algorithm. single-isocenter reoptimized for...
Introduction: Pancreatic ductal adenocarcinoma (PDAC) commonly presents later in life with a median age at diagnosis of 70 years. Unfortunately, elderly patients are significantly underrepresented clinical trials. Stereotactic body radiation therapy (SBRT) is promising treatment modality this population as it has demonstrated excellent local control minimal toxicity. We aimed to determine prognostic factors associated outcomes treated SBRT. Materials and Methods: Elderly older than SBRT for...
Compared with the rest of United States, population Appalachia has lower education levels, higher rates poverty, and limited access to health care. The presence disparities in radiation therapy (RT) for Appalachian patients cancer rarely been examined.The National Cancer Institute initiatives toward addressing treatment rural populations were examined. An extensive literature search was undertaken studies investigating RT patients, beginning most common cancers these (lung, colorectal,...