A5021047030- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Hearing Loss and Rehabilitation
- High-Energy Particle Collisions Research
- Neuroscience and Music Perception
- International Science and Diplomacy
- Alkaline Phosphatase Research Studies
- Bone health and treatments
- Acoustic Wave Phenomena Research
- Neutrino Physics Research
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Radiation Therapy and Dosimetry
- Multisensory perception and integration
- X-ray Spectroscopy and Fluorescence Analysis
- Immune Cell Function and Interaction
- Graphite, nuclear technology, radiation studies
- Bone Metabolism and Diseases
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Regulation of Appetite and Obesity
University of Liverpool
2024
Petronas (Malaysia)
2024
Aston University
2006-2022
Fermi National Accelerator Laboratory
2007-2020
Coventry (United Kingdom)
2017-2018
Alaska Heart and Vascular Institute
2015
Audiology (United States)
2009-2010
EA Technology
2009
University of Birmingham
2004-2006
New Frontier
1995-2003
The TNF receptor (TNFR) family plays a central role in the development of immune response. Here we describe reciprocal regulation recently identified TNFR superfamily member herpes virus entry mediator (HVEM) (TR2) and its ligand LIGHT (TL4) on T cells following activation mechanism this process. cell resulted down-regulation HVEM up-regulation LIGHT, which were both more pronounced CD8(+) than CD4(+) lymphocytes. analysis mRNA showed an increase steady state level mRNAs stimulation. was...
TR2 (TNFR-related 2) is a recently identified member of the TNFR family with homology to TNFRII. We have demonstrated previously that mRNA expressed in resting and activated human T cells TR2-Ig partially inhibits an allogeneic mixed leukocyte proliferation response. now characterize further by use specific mAbs. Flow-cytometry analysis using mAbs confirmed PBL express high levels cell surface TR2, widely on all freshly isolated lymphocyte subpopulations. However, stimulation purified either...
Cathepsin K is a member of the papain superfamily cysteine proteases and has been proposed to play pivotal role in osteoclast-mediated bone resorption. We have developed sensitive cytochemical assay localize quantify osteoclast cathepsin activity sections osteoclastoma human bone. In tissue sections, osteoclasts that are distant from express high levels messenger RNA (mRNA) protein. However, majority these cells an inactive zymogen form, as assessed using both specific immunostaining....
We have characterized four monoclonal antibodies (mAbs) to the purple ("tartrate-resistant," band 5) acid phosphatase of human osteoclast (TRAP) and used these develop a specific serum immunoassay. All mAbs are high affinity (Ka = 1-5 x 10(8) L/mol) with very fast Kassoc (0.2-2.0 10(5) L mol-1 s-1) moderate Kdissoc (1-3 10(-3) s). Two were selected time-resolved fluorescence immunoassay measure concentrations TRAP. The mean immunoreactive TRAP in group healthy premenopausal women men was 3.7...
We report on a search for the photoproduction of ${D}^{0}({\overline{D}}^{0})$ mesons in events which have zero total visible strangeness. observe an enhancement 94\ifmmode\pm\else\textpm\fi{}19 ${K}^{\ifmmode\pm\else\textpm\fi{}}{\ensuremath{\pi}}^{\ensuremath{\mp}}$ decay mode, corresponding to cross section \ensuremath{\sim}720 nb assuming branching ratio 0.018.
Open-heart surgery with fibrillatory arrest has been reported to be associated an increased risk of stroke. We examined whether minimally invasive mitral valve conferred a higher stroke/transient ischaemic attack (TIA) and other major complications compared median sternotomy cardioplegic arrest.Data were collected prospectively for 387 patients who had surgery; 239 surgical approach 148 sternotomy. All surgeries performed by surgeons experienced in techniques. The effect operative on...
Abstract Tartrate-resistant acid phosphatase (TRAP), an enzyme expressed in bone-resorbing osteoclasts, is secreted into the circulation during bone resorption. We used six monoclonal antibodies (MAbs) to optimize direct two-site fluoroimmunoassays for determining serum TRAP concentrations. Four of MABs, 1F1, 2H1, 4E6, and 5C1, were raised against recombinant human TRAP, other two, O1A J1B, TRAP. appeared be highly specific 1F1 4E6 poor recognizing not useful assay. while having a good...
A resonance is observed in the diffractively photoproduced two-pion final state with a mass of \ensuremath{\sim} 1600 MeV and width 300 MeV. The four-pion distribution characterized by 600 peaks around 1500
Photoproduction of the ${{D}^{*}}^{+}$ have been observed where decays via ${{D}^{*}}^{+}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{D}^{0}$ and ${D}^{0}$ ${K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ ${K}_{s}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$. The ${{D}^{*}}^{+}$, mass difference here are in excellent agreement with previous measurements charmed mesons produced ${e}^{+}{e}^{\ensuremath{-}}$ annihilations. photoproduced ${{D}^{*}}^{\ensuremath{-}}$ signals nearly...
For more than 25 years, the Tevatron was highest-energy accelerator in world. It provided first access to particle collisions beyond 1 TeV and achieved an ultimate performance that a factor of 400 original design goals. This article reviews many formidable challenges were overcome, knowledge gained, building, operating, improving during its lifetime. These included operation based on superconducting magnets; production antiprotons sufficient numbers support usable luminosity; management...
For more than two decades the Tevatron proton-antiproton collider was centerpiece of world's high energy physics program. The arguably one most complex research instruments ever to reach operation stage and is widely recognized for numerous discoveries many technological breakthroughs. In this article we outline historical background that led construction Collider, strategy applied evolution performance goals over Tevatron's operational history, briefly describe operations each accelerator...
Conventional hybridomas and combinatorial Ab libraries were used to develop neutralizing murine mAbs human IL-5. Mice immunized with rIL-5. Spleens from two mice generate hybridomas. an additional three construct a library. In both instances, Abs identified selected by ELISA using 96-well plates coated These tested for the ability block binding of iodinated rIL-5 alpha-chain IL-5 receptor (IL-5R alpha) inhibit proliferation IL-5-dependent cells. By hybridoma technology, 16 obtained, 11 which...
The Fermilab Main Injector is a new 150 GeV synchrotron under construction at the Fermi National Accelerator Laboratory. FMI has been designed to support factor of five increase in luminosity available from Tevatron proton-antiproton collider while simultaneously providing 2 mA resonantly extracted 120 proton beam. Recently antiproton storage ring, Recycler, incorporated within scope project with an expected gain two. Project status, schedule for completion, and performance characteristics...
A multi-MW proton facility, Project X has been proposed and is currently under development at Fermilab. As part of this program, we are constructing a prototype the front end linac The construction successful operations facility will validate concept for end, thereby minimizing primary technical risk element within Project. Injector Experiment (PXIE) can be constructed over period FY12-16 include an H- ion source, CW 2.1-MeV RFQ two SC cryomodules providing up to 30 MeV energy gain average...
ABSTRACT Encephalomyocarditis virus (EMCV) has for decades served as an important model RNA virus. Although most of the EMCV proteins are obtained via proteolytic cleavage a long polyprotein, 2B* is expressed from short overlapping open reading frame unusual protein-stimulated temporally dependent ribosomal frameshifting mechanism. The function not yet been characterised, though mutant viruses that unable to express have small plaque phenotype. Here we show binds all seven members 14-3-3...