A5101545972- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Lysosomal Storage Disorders Research
- HIV/AIDS Research and Interventions
- Biotechnology and Related Fields
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Vector-borne infectious diseases
- Malaria Research and Control
- Autophagy in Disease and Therapy
Providence College
2023
University of California, San Diego
1994
QIMR Berghofer Medical Research Institute
1989
Human immunodeficiency virus type 1 (HIV-1) isolates from perinatally infected infants and children were examined for syncytium-inducing (SI) capacity. All 14 <1 year old had non-syncytium-inducing (NSI) HIV-1 phenotypes. Within their first year, 10 progressed to AIDS 3 died. Of 26 >2 years old, 13 SI phenotypes NSI strains. Children with significantly lower CD4+ cell counts standardized age older than those strains (P = .008 .001, respectively);the effect of viral phenotype on lymphocytes...
Lysosomes play important roles in catabolism, nutrient sensing, metabolic signaling, and homeostasis. NPC1 deficiency disrupts lysosomal function by inducing cholesterol accumulation that leads to early neurodegeneration Niemann-Pick type C (NPC) disease. Mitochondria pathology deficits deficient cells are associated with impaired proteolysis signaling. It is thought activation of the transcription factor TFEB, an inducer lysosome biogenesis, restores lysosomal-autophagy activity storage...