A5103022231- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Nuclear Structure and Function
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- RNA regulation and disease
- Diet and metabolism studies
- Tryptophan and brain disorders
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
Sapienza University of Rome
2022-2025
Highlights•Platelets are key link in body-brain communication homeostasis•Platelets tune parvalbumin neuron activity and long-term potentiation the hippocampus•Natural killer cells release IL-13 gut with effects on serotonin uptake by platelets•Platelets NK fear memory miceSummarySeveral lines of evidence have shown that platelet-derived factors molecules brain-body pathological conditions. Here, we identify platelets as actors modulation behaviors mice through control inhibitory...
Abstract Lamin A/C is a nuclear type V intermediate filament protein part of the meshwork structure underlying inner membrane (nuclear lamina), which plays numerous roles, including maintenance shape, heterochromatin organization, and transcriptional regulation. Our group has demonstrated role in different pathophysiological conditions. Here, we investigated for first time how affects neuronal maturation rat cerebellar granule cells (GCs). Primary GCs where silenced Lmna gene constituted our...
All cells are capable of secreting extracellular vesicles (EVs), which not a means to eliminate unneeded cellular compounds but represent process exchange material (nucleic acids, lipids and proteins) between different cells. This also happens in the brain, where EVs permit crosstalk neuronal non-neuronal cells, functional homeostatic processes or responses pathological stimuli. In brain tumors, responsible for bidirectional glioblastoma healthy among them, astrocytes, that assume...