A5091980222- Viral gastroenteritis research and epidemiology
- Synthesis of Organic Compounds
- Viral Infections and Immunology Research
- Oxidative Organic Chemistry Reactions
- SARS-CoV-2 and COVID-19 Research
- Enzyme-mediated dye degradation
Oklahoma State University
2024
China Agricultural University
2023
The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. papain-like protease (PL pro ) is a promising but challenging drug target. We designed synthesized 85 noncovalent PL inhibitors that bind to recently discovered ubiquitin binding site the known BL2 groove pocket near S4 subsite. Leads inhibited with inhibitory constant K i values from 13.2 88.2 nanomolar. co-crystal structures eight leads revealed their interaction modes. in vivo lead...
Laccase is a key enzyme in the fungal 1,8-dihydroxynaphthalene (DHN) melanin biosynthesis pathway, which potential target for control of pathogenic fungi. In our previous work, compound a2 was found with higher inhibition activity against laccase and antifungal than inhibitor PMDD-5Y. The introduction hydrogen-bonded receptors amino part to be beneficial improving inhibitory by target-based-biological rational design. this morpholine piperazine were introduced structure optimization...