A5077573514- Immune cells in cancer
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Ocular Infections and Treatments
Universidade de São Paulo
2024
Universidade do Estado de Minas Gerais
2023
Universidade Federal de Minas Gerais
2020-2023
Bacillus Calmette-Guérin (BCG) is the first line treatment for bladder cancer and it also proposed melanoma immunotherapy. BCG modulates tumor microenvironment (TME) inducing an antitumor effective response, but immune mechanisms involved still poorly understood. The profile of B16-F10 murine cells was assessed by infecting these with or stimulating them agonists different innate pathways such as TLRs, inflammasome, cGAS-STING type I IFN. did not respond to any those stimuli, except IFN...
Abstract BCG (Bacillus Calmette-Guérin) vaccine has been proposed in clinical trials for the treatment of melanoma since 1970, however its mechanism action still not fully understood. The purpose this study was to investigate immune mechanisms involved immunotherapy against melanoma. We first characterized immunological profile mouse B16–F10 cell line compared BMDMs (bone marrow-derived macrophages) infected with or stimulated agonists different innate pathways. were only capable respond...