A5103212304- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Treatments and Studies
- Genomics and Rare Diseases
- Tumors and Oncological Cases
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
Aarhus University Hospital
2024
Aarhus University
2024
Minnesota Department of Health
2018
Abstract Plasma cell-free DNA (cfDNA) originates from apoptotic cells in the blood, providing a real-time insight into biology of various cell types. The fragment coverage pattern cfDNA across genome is known to reflect distinct chromatin status originating cells. While extensive research has focused on fragments derived cancer, as circulating tumor (ctDNA), for inference about cancer biology, healthy have received little attention. Our study explores potential decipher relative abundance...
Cancer of unknown primary (CUP) tumors are biologically very heterogeneous, which complicates stratification patients for treatment. Consequently, these face limited treatment options and a poor prognosis. With this study, we aim to expand on the current knowledge CUP biology by analyzing two cohorts: well-characterized cohort 44 patients, 213 metastatic with known primary. These cohorts were treated at same institution characterized identical molecular assessments. Through comparative...
Abstract Background Multidrug-resistant tuberculosis (MDR TB) is more difficult to treat and outcomes are worse than for drug-susceptible TB disease. MDR cases in Minnesota increased from zero 2015 nine 2016. Case investigations suggested an outbreak. We describe the public health response, challenges of contact (CIs), ongoing management contacts. Methods CDC performed whole-genome sequencing (WGS) evaluate relatedness isolates. conducted CIs infectious cases. created outbreak specific...