A5038397356- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Trypanosoma species research and implications
- Platelet Disorders and Treatments
- Research on Leishmaniasis Studies
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Alcohol Consumption and Health Effects
- Ion Transport and Channel Regulation
- Renal Diseases and Glomerulopathies
- Galectins and Cancer Biology
- Mosquito-borne diseases and control
- Thyroid Cancer Diagnosis and Treatment
- Nuclear Structure and Function
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Malaria Research and Control
- Proteoglycans and glycosaminoglycans research
- Circadian rhythm and melatonin
- Congenital Heart Disease Studies
Doctors Hospital at Renaissance
2025
Hospital Clínico Universitario Lozano Blesa
2024
Instituto de Investigación Sanitaria Aragón
2023-2024
Universidad de Zaragoza
2023-2024
Universidad Nacional de Colombia
2007-2019
Karolinska University Hospital
1997-2009
University of Zulia
2003-2004
Karolinska Institutet
1991-1999
Texas A&M University
1998
University of Oxford
1997
Cell surface GLUT4 levels in skeletal muscle from nine type 2 diabetic subjects and healthy control have been assessed by a new technique that involves the use of biotinylated photo-affinity label. A profound impairment translocation to cell response insulin was observed patients. Levels insulin-stimulated above basal patients were only approximately 10% those subjects. The magnitude defect greater than for glucose transport activity, which 50% Reduced is therefore major contributor impaired...
Thyroid storm is a complex medical diagnosis that, due to its lower incidence in general, can be challenging assess if clinicians do not include it their differential diagnosis. If diagnosed late, trigger life-threatening cardiac arrhythmia and multi-organ failure, leading death. Here, we report the case of 40-year-old female patient with an initial complaint sore throat. After being treated for possible bacterial infection, was then found that she had abnormal thyroid levels viral...
Since ethanol impairs polymorphonuclear leukocyte(PMNL) delivery to inflammatory sites, the effect of on PMNL adhesiveness was studied in vitro. Ethanol inhibited aggregation induced by formylmethionylleucylphenylalanine (FMLP) but not phorbol myristate acetate (PMA), whereas responses both stimuli were abolished treating with monoclonal antibody 60.3 (against adhesion protein CD18). This also abrogated spontaneous and FMLP-stimulatedPMNLadhesion plastic, reduced FMLP-inducedadherence....
El síndrome de Cornelia Lange (SCdL) es una enfermedad rara congénita del desarrollo con afectación multisistémica. Las manifestaciones clínicas son muy variables, pero se distingue entre un fenotipo clásico, caracterizado por unos rasgos craneofaciales distintivos, retraso crecimiento pre y posnatal, defectos reducción las extremidades, hirsutismo discapacidad intelectual, no generalmente más leve difícil diagnosticar. Además, características superponen otros trastornos neurodesarrollo, lo...
Methylene blue (MB) is the oldest synthetic antimalarial. It not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50% parasite growth in vitro late rings early trophozoites most stages; while rings, schizonts less sensitive. Drug interaction study following fractional inhibitory concentrations (FIC) method antagonism with...
Many vertebrate small nuclear RNA gene promoters contain an SPH motif in their distal control regions that can confer transcriptional stimulation by polymerase II or III. Using the human U6 as a probe, we isolated cDNA encoding SPH-binding factor (hSBF) from HeLa cell expression library. The coding region of hSBF is almost identical to ZNF143, 626 amino acid, seven zinc finger protein previously unknown function. Furthermore, predicted acid sequence highly homologous Xenopus laevis and mouse...
Background. The anti-apoptotic properties of melatonin have been demonstrated previously in several vivo and vitro studies. Previous reports shown increased apoptosis during puromycin aminonucleoside nephrosis (PAN). aim this study was to determine if (MEL) can prevent modify oxidative stress, an inducer, experimental model.
Cornelia de Lange syndrome (CdLS) is a rare congenital developmental disorder with multisystemic involvement. The clinical presentation highly variable, but the classic phenotype, characterized by distinctive craniofacial features, pre- and postnatal growth retardation, extremity reduction defects, hirsutism intellectual disability can be distinguished from nonclassic which generally milder more difficult to diagnose. In addition, features overlap those of other neurodevelopmental disorders,...
Previous reports have demonstrated the presence of streptococcal erythrogenic toxin type B (ETB) as well proliferation and expression adhesion molecules along with leukocyte infiltrations in biopsies from patients acute post-streptococcal glomerulonephritis (APSGN). The purpose present study was to correlate infiltrative proliferative events interactions between ETB or its precursor (ETBP) intrinsic mesangial cells.Rat cells were cultured ETBP (50 micro g/ml) while measuring production...
Several recombinant Trypanosoma cruzi proteins previously isolated were used as antigens to analyse antibody specificities present in sera from human infections. Some parasite such SAPA (Shed Acute Phase Antigen) are antigenic early after infection. Others, like 1 and 30, mainly during the chronic phase of To understand why different at periods infection, antibodies infected mice compared with expressed by parasites collected directly blood. Parasites acute parasitaemia peak not only antigen...
Cornelia de Lange syndrome (CdLS, OMIM #122470, #300590, #300882, #610759, and #614701) is a rare congenital disorder that affects the development of multiple organs characterized by physical abnormalities cognitive behavioral disabilities. Its molecular basis mainly based on alterations in genes encoding structural regulatory proteins related to cohesin complex. Moreover, other transcriptional factors have been linked this syndrome. However, additional causative are still unknown, since...
Abstract: Adhesion to cells and matrices participates in the regulation of lymphocyte proliferation, maturation tissue localization. Consequently, abnormal patterns adhesion molecule expression may contribute pathophysiology lymphoprohferative disorders. Integrins are major cell‐surface adhesive proteins composed by a β subunits. In contrast normal lymphocytes, Burkitt's lymphoma (BL) lack β2 integrin CD11a/CD18. To study molecular mechanism underlying this deficiency, presence transcript...
PACS1 neurodevelopmental disorder (PACS1-NDD) (MIM# 615009) is a rare autosomal dominant disease characterized by delay, dysmorphic facial features, and congenital malformations. Heart (HD) frequently present in individuals with PACS1-NDD, but compressive review of these anomalies an evaluation cardiac function cohort patients are lacking.(i) Cardiac 11 PACS1-NDD was conducted using conventional echocardiography. (ii) assessed tissue Doppler imaging, two-dimensional speckle tracking...
Introducción: la obesidad se ha asociado con mayor densidad mineral ósea (DMO), sin embargo, recientes estudios reportan que pudiese conllevar incremento de resorción y, por ende, riesgo fractura. Metodología: estudio corte transversal analítico en donde incluyeron hombres entre 18 y 30 años quienes realizaron diversas mediciones hormonales (insulina, testosterona libre total, IGF-1, estradiol, leptina adiponectina), bioquímicas (PTOG-glucosa, colesterol cHDL, cLDL, proteína C reactiva...