A5048821779- Peptidase Inhibition and Analysis
- Muscle Physiology and Disorders
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Ubiquitin and proteasome pathways
- Animal Nutrition and Physiology
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- CAR-T cell therapy research
- Exercise and Physiological Responses
- Meat and Animal Product Quality
- Protein Degradation and Inhibitors
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Silk-based biomaterials and applications
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Tissue Engineering and Regenerative Medicine
- Animal Genetics and Reproduction
- PARP inhibition in cancer therapy
- Neurogenetic and Muscular Disorders Research
- Retinoids in leukemia and cellular processes
- Hearing, Cochlea, Tinnitus, Genetics
- Wnt/β-catenin signaling in development and cancer
King's College London
1995
Institute of Cancer Research
1992
MRC Clinical Trials Unit at UCL
1992
The Honourable Society of Lincoln's Inn
1992
Guy's Hospital
1990
Muscular Dystrophy UK
1989
National Hospital for Neurology and Neurosurgery
1988-1989
University College London
1988-1989
University of London
1983-1985
Imperial College London
1982-1983
1. Five major fibre types in chicken skeletal muscles are recognized, based upon their histochemical and morphological characteristics. A classification of these which is readily related to a commonly used mammalian muscle given. 2. Seven the were analysed recognizing this range types. The proportions different each determined. In some cases gradient type composition exists across single muscle. 3. Measurements contraction defining tonic muscles, contain two It was shown that addition...
Abstract Purpose: CD137 is a T- and NK-cell costimulatory receptor involved in consolidating immunologic responses. The potent agonist urelumab has shown clinical promise as cancer immunotherapeutic but development been hampered by on-target off-tumor toxicities. A targeted to the prostate-specific membrane antigen (PSMA), frequently highly expressed on castration-resistant metastatic prostate (mCRPC) tumor cells, could bring effective immunotherapy this immunologically challenging address...
Mouse 3T3 fibroblasts were permanently transfected with cDNAs encoding isoforms of the neural cell adhesion molecule (N-CAM) present in human skeletal muscle and brain. Parental cells then used a range assays. In absence external shear forces, transfection either transmembrane or glycosylphosphatidylinositol (GPI)-linked N-CAM species significantly increased intercellular adhesiveness suspension. Transfection cDNA secreted isoform was without effect on adhesion. Cells containing lacking...
We have examined dystrophin mRNA in embryonic, newborn and adult mouse skeletal muscle. A discrete nerve‐independent increase size was observed between embryonic stages, indicating that a developmentally regulated isoform switch occurs the expression of Duchenne muscular dystrophy (DMD) gene These distinct mRNAs are most likely generated via selection alternative transcriptional start sites or RNA processing pathways. In addition, denervation muscle without effect on pattern.
Using a sensitive and quantitative adhesion assay, we have studied the initial stages of intercellular C2 mouse myoblast line. After dissociation in low levels trypsin EDTA, cells can rapidly reaggregate by Ca2+-independent mechanisms to form large multicellular aggregates. If are allowed recover from incubation defined media, this adhesive system is augmented Ca2+-dependent mechanism with maximum recovery seen after 4 h incubation. The inhibited preincubation cell monolayers cycloheximide...
Cultured skin fibroblasts from normal individuals and patients with Duchenne muscular dystrophy spread equally rapidly when seeded on a glass substratum. Exposure to the ionophore monensin substantially suppresses dystrophic fibroblast spreading in serum-free media for up at least 100 min. Preincubation of causes further reduction cell spreading. Dystrophic fail as well cells after preincubation. Such findings indicate that there is delay secretion functional adhesive surface proteins...
Pizzey J.A.&Barnard E.A.(1983) Neuropathology and Applied Neurobiology 9, 149–164 Structural change in muscles of the dystrophic chicken. II. Progression histopathology pectoralis muscle Dystrophic (D) normal (N) chicken pectoral was analysed for histopathological differences from embryo (day 20) through to mature adult stage. A variety indices structural changes were used, express progression quantitatively. At embryonic stage, fibroblast numbers (but not satellite cell numbers) are...
The pectoral and posterior latissimus dorsi (PLD) muscles in the dystrophic chicken show many pathological changes. At 7 weeks of age, a strain these birds bred for early onset this inherited disorder, physical weakness is established changes can be clearly assessed. Quantitative indices progressive were obtained by light electron microscopic analyses; cover fibre hypertrophy, area variation, nuclei distribution, phagocytosis satellite cell fibroblast populations. muscle at more severely...
Abstract INTRODUCTION: CD137 is a T and NK cell costimulatory receptor involved in consolidating immunological responses. The potent agonist urelumab has shown clinical promise as cancer immunotherapeutic but development been hampered by on-target off-tumour toxicities. A targeted to the prostate-specific membrane antigen (PSMA), frequently highly expressed on castration-resistant metastatic prostate (mCRPC) tumour cells, could bring effective immunotherapy this immunologically challenging...
Zfp-37 is a zinc finger protein gene expressed in male germ cells. The cDNA detected two transcripts on Northern blots of testis RNA, with expression first at around day 19. To establish the pattern we have raised antibodies to ZFP-37 and used them thin sections Western blots. On antibody proteins exclusively extracts, confirming previous mRNA data. A time-course study revealed that larger appears about 22 but smaller one not until 34. Analysis these purified cell preparations only...
<p>Supplementary Figure 8: Spheroid end-of-study T=240h images</p>
<p>Supplementary Figure 9: Neuroendocrine Differentiation Phenotypes in Prostate Cancer Liver Metastases</p>
<p>Supplementary Figure 10: hPSMA expression on RP1 tumour cells is lost over time, even in tumours dosed with HSA only</p>
<p>Supplementary Figure 9: Neuroendocrine Differentiation Phenotypes in Prostate Cancer Liver Metastases</p>
<div>AbstractPurpose:<p>CD137 is a T- and NK-cell costimulatory receptor involved in consolidating immunologic responses. The potent CD137 agonist urelumab has shown clinical promise as cancer immunotherapeutic but development been hampered by on-target off-tumor toxicities. A targeted to the prostate-specific membrane antigen (PSMA), frequently highly expressed on castration-resistant metastatic prostate (mCRPC) tumor cells, could bring effective immunotherapy this...
<p>Supplemental Methods</p>
<p>Supplementary Figure 3: PK/TK dosing strategies</p>
<p>Supplementary Figure 8: Spheroid end-of-study T=240h images</p>
<p>Supplementary Figure 11: Vipivotide tetraxetan does not interfere with CB307 activity</p>
<p>Supplementary Figure 5: CB307 binding to cell-presented targets</p>
<p>Supplementary Figure 5: CB307 binding to cell-presented targets</p>