A5028414361- Marine Sponges and Natural Products
- Research on Leishmaniasis Studies
- Helminth infection and control
- Medicinal Plants and Neuroprotection
- Synthesis and Biological Activity
- Trypanosoma species research and implications
- Neurobiology and Insect Physiology Research
- Insect Pest Control Strategies
- Insect Utilization and Effects
- Andrographolide Research and Applications
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
University of the Ryukyus
2021-2024
IPB University
2021
A merosteroid with a flexible side chain named varicosenone (1a) was isolated from the sea slug Phyllidia varicosa collected Banten, Jakarta, and South Sulawesi, Indonesia. The structure of 1a elucidated using 1D 2D nuclear magnetic resonance (NMR), mass spectrometry (MS) as well density functional theory (DFT)--based NMR calculations. relative configuration for rigid portion (cyclic portion) evidenced by Overhauser effect spectroscopy (NOESY) correlation, while two-chiral centres on were...
Given the continuous emergence of new variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), development inhibitors is necessary to enhance clinical efficacy and increase options for combination therapy disease 2019. Because marine organisms have been a resource discovery numerous bioactive molecules, we constructed an extract library invertebrates collected from Okinawa Islands. In this study, extracts were used identify antiviral molecules against SARS-CoV-2. Using...
Polybrominated diphenyl ether (PBDE) compounds, derived from marine organisms, originate symbiosis between sponges and cyanobacteria or bacteria. PBDEs have broad biological spectra; therefore, we analyzed structure activity relationships of to determine their potential as anticancer antibacterial lead structures, through reactions computational studies. Six known (1-6) were isolated the sponge, Lamellodysdiea herbacea; 13C NMR data for compound 6 are reported first time assignments...
Leishmaniasis is a major public health problem, especially affecting vulnerable populations in tropical and subtropical regions. The disease endemic 90 countries, with millions of people at risk, it seen as one the ten most neglected diseases. Current treatments face challenges such high toxicity, side effects, cost, growing drug resistance. There an urgent need for safer, affordable treatments, cutaneous leishmaniasis (CL), common form. Marine invertebrates have long been resources...