A5066690815- Neuroscience and Neuropharmacology Research
- Protein Kinase Regulation and GTPase Signaling
- Ion channel regulation and function
- Phytoplasmas and Hemiptera pathogens
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- PARP inhibition in cancer therapy
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Estrogen and related hormone effects
- Photoreceptor and optogenetics research
- Immune Cell Function and Interaction
- Neural dynamics and brain function
- Steroid Chemistry and Biochemistry
- Cell death mechanisms and regulation
- Cellular transport and secretion
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Receptors and Signaling
- Retinal Development and Disorders
- Pancreatic function and diabetes
- Hippo pathway signaling and YAP/TAZ
SUNY Downstate Health Sciences University
2012-2024
State University of New York
2012-2024
Jackson Laboratory
2003
Howard Hughes Medical Institute
2003
Yale University
2003
Icahn School of Medicine at Mount Sinai
1997-2000
PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But memory are maintained without in PKMζ-null mice. Two hypotheses can account for these findings. First, unimportant LTP or Second, essential wild-type mice, mice recruit compensatory mechanisms. We find that whereas increases maintenance PKCι/λ, gene-product closely related PKMζ, Using pharmacogenetic approach, we PKMζ-antisense hippocampus blocks spatial but not the target mRNA. Conversely,...
How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding genetically linked human memory performance, complexes with kinase Mzeta (PKMζ), anchoring kinase’s potentiating action late-phase (late-LTP) at synapses. Two structurally distinct antagonists KIBRA-PKMζ dimerization disrupt established late-LTP spatial memory, yet neither measurably...
Protein kinase Mζ (PKMζ) is an atypical protein C isoform that has been implicated in the synthesis-dependent maintenance of long term potentiation and memory storage brain. Synapse-associated kinases are uniquely positioned to promote enduring consolidation structural functional modifications at synapse, provided mRNA available on site for local input-specific translation. We now report encoding PKMζ rapidly transported specifically localized synaptodendritic neuronal domains. Transport...
Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced many cell types. have been shown to be expressed by insulin-producing beta cells mice and humans. However, the importance of development autoimmune diabetes remains controversial. To further evaluate pathogenesis diabetes, we generated NOD (nonobese diabetic developing spontaneous diabetes) with cell-specific expression dominant-negative point mutation domain Fas, known as lpr cg or . Spontaneous was significantly...
Turnover of mRNA is a critical step that allows cells to control gene expression. Endoribonucleases, enzymes cleaving RNA molecules internally, are some the key components degradation process. Here we provide detailed characterization novel endoribonuclease SLFN14 purified from rabbit reticulocyte lysate. Schlafen genes encode family proteins limited mammals. Their cellular function unknown or incompletely understood. In reticulocytes, strongly overexpressed, represented exclusively by short...
Synaptic abnormalities have been implicated in schizophrenia. In order to investigate synaptic pathology schizophrenia, we examined levels of mRNAs encoding synaptophysin, synapsin 1A and 1B the left temporal cortex from schizophrenics (n = 24) normal control individuals with no history psychiatric illness 10). Levels superior middle gyrus declined significantly age schizophrenics, but not controls. Dividing diagnostic groups according (below above 75 years), data revealed that "young" (age...
Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes bone marrow crucial for cessation of bleeding at sites injury. Inherited thrombocytopenias a group disorders characterized by low platelet count frequently associated with excessive bleeding. SLFN14 is one most recently discovered genes linked to inherited thrombocytopenia where several heterozygous missense mutations in were identified cause defective megakaryocyte maturation...
Abstract Cognitive deficits frequently arise after traumatic brain injury. The murine closed head injury (CHI) models these since injured mice cannot acquire Barnes maze. Dosing of minocycline plus N-acetylcysteine beginning 12 hours post-CHI (MN12) restores maze acquisition by an unknown mechanism. Increased hippocampal synaptic efficacy is needed to maze, long-term potentiation (LTP) this increased in vitro . LTP has early phase (E-LTP) lasting up one hour that mediated second messengers...
ABSTRACT Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes bone marrow crucial for cessation of bleeding at sites injury. Inherited thrombocytopenias a group disorders characterized by alow platelet count frequently associated with excessive bleeding. SLFN14 is one most recently discovered genes linked to inherited thrombocytopenia where several heterozygous missense mutations in were identified cause defective megakaryocyte maturation...