Alessandra Pinna

ORCID: 0009-0001-4467-8484
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About
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Research Areas
  • Congenital heart defects research
  • Near-Field Optical Microscopy
  • Nanopore and Nanochannel Transport Studies
  • Lipid Membrane Structure and Behavior
  • Tissue Engineering and Regenerative Medicine
  • Advanced Fluorescence Microscopy Techniques
  • Electrospun Nanofibers in Biomedical Applications
  • Photoacoustic and Ultrasonic Imaging
  • Nanoparticle-Based Drug Delivery

University of Surrey
2024

The Francis Crick Institute
2024

Imperial College London
2024

London Centre for Nanotechnology
2024

Conditions affecting the brain are second leading cause of death globally. One main challenges for drugs targeting diseases is passing blood–brain barrier (BBB). Here, effectiveness mesoporous silica nanostars (MSiNSs) with two different spike lengths to cross an in vitro BBB multicellular model was evaluated and compared spherical nanoparticles (MSiNP). A modified sol–gel single-micelle epitaxial growth used produce MSiNS, which showed no cytotoxicity or immunogenicity at concentrations up...

10.1021/acsami.4c06726 article EN cc-by ACS Applied Materials & Interfaces 2024-07-11

In advancing cardiac tissue engineering (CTE), the development of injectable hydrogels mirroring myocardial properties is pivotal. The designed must not only support cell growth but also have to be conductive properly promote functionalities cells. Here, a facile approach developed incorporate gold nanoparticles (AuNPs) into an hydrogel composed Alginate (Alg) and Gelatin (Gel). resultant nanocomposite boasts porous interconnected network superior conductivity (2.04 × 10-4 S cm

10.1002/mabi.202400301 article EN Macromolecular Bioscience 2024-12-11

Mesoporous silica nanoparticles (MSNPs) are promising nanomedicine vehicles due to their biocompatibility and ability carry large cargoes. It is critical in development be able map uptake cells, including distinguishing surface associated MSNPs from those that embedded or internalized into cells. Conventional nanoscale imaging techniques, such as electron fluorescence microscopies, however, generally require the use of stains labels image both biological material nanomedicines, which can...

10.1021/cbmi.4c00053 article EN cc-by-nc-nd Chemical & Biomedical Imaging 2024-10-19
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