A5082388820- Nuclear Structure and Function
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- Drug Transport and Resistance Mechanisms
- Musculoskeletal pain and rehabilitation
- Multiple Sclerosis Research Studies
- Cannabis and Cannabinoid Research
- Reproductive Health and Contraception
- Ovarian function and disorders
- Pancreatic function and diabetes
- Sexual Differentiation and Disorders
- Ubiquitin and proteasome pathways
- Legal case studies and regulations
- Melanoma and MAPK Pathways
- Biomedical and Chemical Research
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Legal principles and applications
- Archaeological Research and Protection
- Cancer Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
Southeast Clinical Oncology Research Consortium
2018-2024
Emory University
2006-2021
Wake Forest University
2018
Purdue University West Lafayette
2012-2017
California State University, Northridge
2015-2016
California State University System
2015
Korea Research Institute of Bioscience and Biotechnology
2007
Nuclear localization signals (NLSs) are amino acid sequences that target cargo proteins into the nucleus. Rigorous characterization of NLS motifs is essential to understanding and predicting pathways for nuclear import. The best-characterized classical (cNLS), which recognized by cNLS receptor, importin-alpha. cNLSs conventionally defined as having one (monopartite) or two clusters basic acids separated a 9-12 aa linker (bipartite). Motivated finding Ty1 integrase, contains an unconventional...
Proteins destined for import into the nucleus contain nuclear localization signals (NLSs) that are recognized by receptors termed karyopherins or importins. Until recently, only sequence had been well defined and characterized was classical NLS (cNLS), which is importin α. However, Chook coworkers (Lee, B. J., Cansizoglu, A. E., Süel, K. Louis, T. H., Zhang, Z., Chook, Y. M. (2006) Cell 126, 543–558) have provided new insight targeting with their identification of a novel NLS, PY-NLS, human...
Tolbutamide and gliclazide block the K<sub>ATP</sub> channel K<sub>ir</sub>6.2/Sur1, causing membrane depolarization stimulating insulin secretion in pancreatic beta cells. We examined ability of EPAC-selective cAMP analog 8-pCPT-2′-O-Me-cAMP-AM to potentiate action these drugs mechanism that might account for it. Insulin stimulated by both 200 <i>μ</i>M tolbutamide 20 gliclazide, concentrations had equivalent effects on potential, was inhibited thapsigargin (1 <i>μ</i>M) or L-type...
Many atypical antipsychotic drugs currently prescribed for the treatment of schizophrenia have limited brain penetration due to efflux activity ATP-binding cassette (ABC) transporters at blood-brain barrier (BBB), including P-glycoprotein (P-gp) and ABCG2. Herein, we describe design synthesis first class homodimeric prodrug dual inhibitors P-gp These are based on structure drug paliperidone (Pal), a transport substrate both transporters. We synthesized characterized small library bivalent...
The importin α/β transport machinery mediates the nuclear import of cargo proteins that bear a classical localization sequence (cNLS). These are linked to major protein factor, importin-β, by importin-α adapter, after which cargo/carrier complexes enter nucleus through pores. In nucleus, is released action RanGTP and pore Nup2, importins recycled cytoplasm for further cycles. export mediated Cse1/CAS. Here, we exploit structures functionally important identify residues critical these...
We investigated the role of Cav1.2 in pancreatic β-cell function by expressing a II-III loop/green fluorescent protein fusion INS-1 cells (Cav1.2/II-III cells) to disrupt channel-protein interactions. Neither block KATP channels nor stimulation membrane depolarization tolbutamide was different compared with Cav1.2/II-III cells, but whole-cell Cav current density significantly increased cells. Tolbutamide (200 μM) stimulated insulin secretion and Ca(2+) transients were completely blocked...
Abstract Background The Remunity Pump for Remodulin (treprostinil) Injection is an infusion system indicated use with subcutaneous treprostinil. Objective objective was to assess the stability of diluted treprostinil sodium stored in pump cassettes. Methods Treprostinil’s chemical and physical were assessed over a 76-hour period at 40 degrees Celsius 75% relative humidity after dilution 0.01 mg/mL sterile water injection 0.9% chloride. Analyses conducted via visual inspection, pH...
Abstract The figure of Anthony Comstock may seem like an odd historical relic: a repressed, puritanical, anti-sex reformer from bygone past. And yet, because his namesake act has been revived as potential strategy for limiting access to reproductive healthcare, is no joke. Today, some Americans see the Act, passed by Congress in 1873, pathway banning abortion and other care, effectively jettisoning any need new Supreme Court rulings or congressional legislation. As scholars Gilded Age...
Balance deficiencies are common amongst individuals with Multiple Sclerosis (MS), resulting in limited activities of daily living and an increased fall risk. Exercise, especially recently studied aquatic exercise, has been documented to be effective increasing function improving quality life. Limited studies have examined the effects exercise on balance outcomes using biomechanical methods. PURPOSE: The purpose this study was examine program people MS. findings were expected provide more...
Multiple Sclerosis (MS) is a progressive neurodegenerative disease which associated with various physical impairments. These impairments can limit independence in activities of daily living and decrease the level activity, may lead to further deconditioning. Aquatic exercise help people MS improve their function fitness an accommodating environment. PURPOSE: The purpose this study was investigate effects aquatic on gait strength outcomes individuals MS. METHODS: A randomized controlled...