A5098490377- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
Nova Southeastern University
2024
Glucagon-like peptide-1 (GLP-1) is a multifunctional incretin hormone with various physiological effects beyond its well-characterized effect of stimulating glucose-dependent insulin secretion in the pancreas. An emerging role for GLP-1 and receptor, GLP-1R, brain neuroprotection suppression inflammation, has been documented recent years. GLP-1R G protein-coupled receptor (GPCR) that couples to Gs proteins stimulate production second messenger cyclic 3’,5’-adenosine monophosphate (cAMP)....
Sympathetic nervous system (SNS) hyperactivity is mediated by elevated catecholamine (CA) secretion from the adrenal medulla, as well enhanced norepinephrine (NE) release peripheral sympathetic nerve terminals. Adrenal CA production chromaffin cells tightly regulated sympatho-inhibitory α2-adrenergic (auto)receptors (ARs), which inhibit both epinephrine (Epi) and NE via coupling to Gi/o proteins. α2-AR function is, in turn, G protein-coupled receptor (GPCR)-kinases (GRKs), especially GRK2,...
Dapagliflozin is a sodium/glucose co-transporter (SGLT)-2 inhibitor with beneficial cardiovascular effects independent of its antidiabetic actions. Among these sympatholysis, i.e., norepinephrine (NE) lowering, in chronic human heart failure (HF). Adrenal G protein-coupled receptor kinase (GRK)-2 upregulation major driver circulating catecholamine (CA) elevation and sympathetic nervous system (SNS) hyperactivity HF due to dysregulation adrenal sympatho-inhibitory α 2 -adrenergic...