A5038415913- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Pneumonia and Respiratory Infections
- Pediatric Urology and Nephrology Studies
- Asthma and respiratory diseases
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal Health and Biochemistry
- Transgenic Plants and Applications
- Vector-borne infectious diseases
- Bacterial Infections and Vaccines
- Autoimmune and Inflammatory Disorders
- Urological Disorders and Treatments
- Drug-Induced Adverse Reactions
- Bartonella species infections research
- Carcinogens and Genotoxicity Assessment
- Pharmaceutical studies and practices
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Consumer Attitudes and Food Labeling
- Antibiotic Resistance in Bacteria
- Bacillus and Francisella bacterial research
- Ion Transport and Channel Regulation
Sotiria General Hospital
2010-2024
National and Kapodistrian University of Athens
2005-2023
Laiko General Hospital of Athens
2015
Panagiotis & Aglaia Kyriakou Children's Hospital
1988-2005
Karolinska University Hospital
1995
National Centre of Scientific Research "Demokritos"
1988
Children's Hospital Agia Sophia
1973-1974
Alexandra Hospital
1973
Evangelismos Hospital
1972
Institute of Child Health
1972
Background We tested the hypothesis that specific molecular sensitization patterns correlate with clinical data/manifestation in a European peanut-allergic population characterized under common protocol. Methods Sixty-eight subjects and 82 tolerant controls from 11 countries were included. Allergy to peanut lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge all but anaphylactic subjects. Information of early or late (before after 14 years age)...
Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention been given to combining them with clinical factors in predicting severity.To analyze sensitization patterns, patient characteristics history, develop models improve predictive accuracy.Patients reporting allergy (n = 423) from 12 European cities were tested for allergens. Symptoms (reported during Double-blind placebo-controlled...
The heterogeneity and lack of validation existing severity scores for food allergic reactions limit standardization case management research advances. We aimed to develop validate a score reactions.Following multidisciplinary experts consensus, it was decided allergy (FASS) with ordinal (oFASS) numerical (nFASS) formats. oFASS 3 5 grades were generated through expert nFASS by mathematical modeling. Evaluation performed in the EuroPrevall outpatient clinic cohort (8232 reactions) logistic...
The EuroPrevall project aimed to develop effective management strategies in food allergy through a suite of interconnected studies and multidisciplinary integrated approach. To address some the gaps diagnosis, allergen risk socio-economic impact complement population-based surveys, cross-sectional study 12 outpatient clinics across Europe was conducted. We describe protocol.Patients referred for immediate adverse reactions underwent consistent standardized work-up that comprised collection...
Night and day rhythms of HGH secretion were measured in 5 children before any treatment, 10 days after prednisone administration, 3 ACTH treatment. Corticosteroids corticotrophin found to have a pronounced effect on the spontaneous level with almost complete disappearance normally observed peaks during 24 hours pretreatment study. It is postulated that this might explain part growth retardation noticed long-term treatment corticosteroids or corticotrophin.
BackgroundWalnut allergy is common across the globe, but data on involvement of individual walnut components are scarce.ObjectivesTo identify geographical differences in component sensitization Europe, explore cosensitization and cross-reactivity, assess associations clinical serological determinants with severity allergy.MethodsAs part EuroPrevall outpatient surveys 12 European cities, standardized evaluation was conducted 531 individuals reporting symptoms to walnut, all known assessed 202...
The incidence of INH-associated liver injury was evaluated in 239 children aged between 9 and 14 years, who were receiving 300 mg INH/day for tuberculosis prophylaxis. Serum SGOT SGPT levels determined before INH administration at 4-weekly intervals thereafter. Levels both enzymes raised during the first 3 months treatment 18 (7.5%) children, while 23 (9.6%) either or exceeded normal (SGOT greater than 40 units, 30 units). Only 2 (0.8%) showed values above 100 units them with had to be...
Abstract Scope Banana fruit has become an important cause of allergy in the recent years. Among five registered IUIS allergens, Mus a 1 and 2 have been characterized detail. In this study, molecular characterization evaluation allergenic properties β‐1,3‐glucanase from banana ( Musa acuminata ), denoted as 5, were performed Methods results The gene 5 was cloned sequenced. obtained cDNA revealed novel isoform with open reading frame encoding protein 340 amino acids comprising putative signal...
Pru p 3 and 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns five components across Europe in Japan, explore their relation pollen foods predict symptom severity.In twelve European (EuroPrevall project) one Japanese outpatient clinic, a standardized clinical evaluation was conducted 1231 patients who reported symptoms and/or were sensitized peach. Specific IgE against 1, 2, 3, 4 Cup s measured 474 of them. Univariable...
Abstract The potential genotoxicity of nitrates and nitrites—contaminants drinking water that have been implicated in carcinogenesis—was investigated this study. Sister chromatid exchanges frequency chromatid/hromosome aberrations were studied peripheral blood lymphocytes 70 children who 12–15 y age. These permanent residents geographical areas Greece, where elevated concentrations (i.e., 55.70–87.98 mg/l) existed water. control group comprised 20 healthy resided with very low nitrate 0.7...
Abstract Background European legislators and wine producers still debate on the requirement for labeling of wines fined with potentially allergenic food proteins (casein, egg white or fish‐derived isinglass). We investigated whether known concentrations these have potential to provoke clinical allergic reactions in relevant patients. Methods In‐house were produced study, different casein (n = 7), albumin 1) isinglass 3). ELISA PCR kits specific respective used identify fining agents. Skin...
Abstract Background Sensitization to hazelnut allergens vary depending on the geographic origin and age of patients. The objective this study was further investigate allergenic activity using sera from patients recruited in various European regions presenting different sensitization patterns proteins. Methods Natural Cor a 11 9 were purified whereas 1 8 produced as recombinant proteins (rCor 1.04 rCor 8). Sera allergic collected France ( n = 5), Switzerland 2), Greece 11) Spain 3), within...
Cefotaxime is a new cephalosporin with spectrum of activity which may make it appropriate for use in pediatric patients. In 33 infants and children, administration cefotaxime resulted cure or improvement 97% patients, eradication 94% isolated pathogens. Toxicity was minimal. The disposition this age group similar to that reported adults, an elimination half-life approximately 1.5 h, volume distribution 1 liter/kg, total serum clearance 10 ml/min per kg, renal 6 kg.
The pharmacokinetic properties of amikacin sulfate in infants and children aged from three weeks to 6 years were studied during treatment with doses 7.5 mg/kg every 12 hours using standard assay methods technique two compartment open model kinetic analysis. Peak serum concentrations measured 30 or 60 min after the first intramuscular injection. These ranged 11.8 microgram/ml 23 9.0 29 children. Five minutes intravenous bolous injection they varied 16 29.8 34 42 Twelve less than 0.8 all...
Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects mild-to-moderate and severe PA, investigate individual collective predictive accuracy background IgE to extract components for PA severity. Methods: Data on demographics, patient history sensitization at component level 393 probable (symptoms ≤ 2 h + sensitization) from 12 EuroPrevall centers were analyzed. Univariable...
Eosinophilic gastrointestinal diseases (EGIDs) are a group of chronic conditions, characterized by an excessive accumulation eosinophils in various areas the mucosal (GI) tract. EGIDs encompass spectrum diseases, including eosinophilic esophagitis (EoE), gastritis (EoG), enteritis (EoN), and colitis (EoC), each affecting different segments GI The pathogenesis is multifaceted involves intricate interplay between genetic predisposition, environmental triggers, dysregulated immune responses....
Cat-scratch disease is considered in the differential diagnosis of benign regional lymphadenopathy. We describe a case cat-scratch 12-year-old boy with multiple bony, hepatic and splenic lesions which resolved chemotherapy. The present simultaneous multiorgan involvement supports view systemic nature disease.
Fish allergens represent one of the most common causes adverse reactions to food worldwide. Double-blind placebo-controlled challenges (DBPCFC) are gold standard for allergy diagnosis. However, no standardised recipes available such as fish, and a well trained dietitian is essential creating standardising them. The present study aimed create standardise use in DBPCFCs fish.Three were prepared. Employing procedure, total 35 panelists evaluated different matrices using an evaluation form. A...