A5058593589- Electrospun Nanofibers in Biomedical Applications
- Microtubule and mitosis dynamics
- Polymer composites and self-healing
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Additive Manufacturing and 3D Printing Technologies
- Bacterial Infections and Vaccines
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Outbreaks Research
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
Università Cattolica del Sacro Cuore
2023-2024
Sapienza University of Rome
2021
Abstract The COVID-19 pandemic caused by SARS-CoV-2 has highlighted the urgent need for innovative antiviral strategies to fight viral infections. Although a substantial part of overall effort been directed at Spike protein create an effective global vaccination strategy, other proteins have also examined and identified as possible therapeutic targets. Among them, although initially underestimated, there is E-protein, which turned out be key factor in pathogenesis due its role virus budding,...
Abstract This study aims to obtain a cyto‐compatible 3D printable bio‐resin for the manufacturing of meshes designed from acquired real patients’ bone defect be used in future guided regeneration (GBR), achieving goal personalized medicine, decreasing surgical, recovery time, and patient discomfort. To this purpose, biobased, biocompatible, photo‐curable resin made acrylated epoxidized soybean oil (AESO) diluted with (SO) is developed printed using commercial digital light processing (DLP)...
Multiple Sclerosis (MS) is a chronic inflammatory disease that affects the brain and spinal cord. Inflammation, demyelination, synaptic alteration, neuronal loss are hallmarks detectable in MS. Experimental autoimmune encephalomyelitis (EAE) an animal model widely used to study pathogenic aspects of Autophagy process maintains cell homeostasis by removing abnormal organelles damaged proteins involved both protective detrimental effects have been seen variety human diseases, such as cancer,...
In the field of regenerative medicine, acrylated epoxidized vegetable oils are emerging as a promising avenue exploration. The aim this study is to evaluate degradability two formulations soybean oil (AESO): pure AESO and diluted with (SO) for potential bioprintability applications. comprehensive investigation these polymeric included optimization polymerization conditions, confirmation cytocompatibility, and, most importantly, their degradability. results reveal that AESO, used biomaterial...
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized intracellular deposition of polymers (NS), which leads to proteotoxicity and cell death. Despite different animal models developed thus far, exact mechanism toxicity elicited NS remains unclear. Here, we report that wild-type polymerogenic variant G392E form protein aggregates mainly localized within endoplasmic reticulum (ER) when...