A5042579094- Marine and coastal ecosystems
- Arctic and Antarctic ice dynamics
- Oceanographic and Atmospheric Processes
- Geophysics and Gravity Measurements
- Bee Products Chemical Analysis
- earthquake and tectonic studies
- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- Advancements in Transdermal Drug Delivery
- Polar Research and Ecology
- Ocean Acidification Effects and Responses
- Environmental Monitoring and Data Management
- demographic modeling and climate adaptation
- Marine Biology and Ecology Research
- Skin Protection and Aging
- CAR-T cell therapy research
- Methane Hydrates and Related Phenomena
Princess Margaret Cancer Centre
2024
University Health Network
2024
Korea Institute of Ocean Science and Technology
2011
The University of Tokyo
2000-2006
Anti-aging products are widely used, but the desire for safe and more efficient anti-aging continues to increase. Dissolving microneedle patches (MNPs) have provided a transdermal drug delivery solution. MNP is promising candidate developing better products.
<h3>Background</h3> Adoptive transfer of T cell receptor gene-engineered (TCR-T) cells can induce durable anti-cancer responses. TBI-1301 is a novel gene therapy produced by engineering autologous lymphocytes to express an NY-ESO-1-specific TCR using retrovirus vector encoding siRNA silence endogenous TCR. In this study, we characterize long-lived persisting transferred TCR-T following adoptive at the single-cell level. <h3>Methods</h3> Patients eligible for approved study (UHN REB 15-9534)...
국립해양조사원 39개소 조위관측소의 후빙기조륙운동(Glacial Isostatic Adjustment, GIA)에 의한 지각변동 속도를 ICE-3G와 ICE-5G 모델로 예측하였다. 또한 위도 <TEX>$32^{\circ}-38.5^{\circ}N$</TEX>, 경도 <TEX>$124^{\circ}-132^{\circ}E$</TEX> 범위의 한반도 지역을 <TEX>$0.5^{\circ}{\times}0.5^{\circ}$</TEX> 격자로 분할하고 각 격자점에서의 GIA 계산하였다. 그 결과 ICE-3G 모델의 경우 수직 지각변동은 평균 0.33 mm/yr이고, 1.21 mm/yr의 속도로 지각변위가 발생하는 것으로 나타났다. 최신 Ice model인 모델을 사용할 한반도에서도 약 1 mm/yr 이상의 비교적 높은 지각변동이 발생하므로 절대해수면 변동을 산정하기 위해서 GIA에 수직변위를 보정해야 함을 확인하였다. 따라서 국립해양조사원에서 제공하는 13개 상대해수면 변동률에서...