A5009453817- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Biochemical and Molecular Research
- RNA regulation and disease
- Eosinophilic Disorders and Syndromes
- Protein Kinase Regulation and GTPase Signaling
- RNA Research and Splicing
- Chromatin Remodeling and Cancer
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Protein Tyrosine Phosphatases
Iowa State University
2021-2024
Fred Hutch Cancer Center
2023
Northeastern University
2023
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK date consists the autoinhibited SH3–SH2–kinase core. Precisely how N-terminal domains (the Pleckstrin homology/Tec homology [PHTH] domain and proline-rich regions [PRR] contain linker) contribute regulation remains unclear. We have produced crystals for first time but despite efforts stabilize state, diffraction data still reveal only core with no electron density...
Full-length BTK has been refractory to structural analysis. The nearest full-length structure of date consists the autoinhibited SH3-SH2-kinase core. Precisely how N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and proline-rich regions (PRR) contain linker) contribute regulation remains unclear. We have produced crystals for first time but despite efforts stabilize state, diffraction data still reveals only core with no electron density visible PHTH-PRR segment....
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK date consists the autoinhibited SH3–SH2–kinase core. Precisely how N-terminal domains (the Pleckstrin homology/Tec homology [PHTH] domain and proline-rich regions [PRR] contain linker) contribute regulation remains unclear. We have produced crystals for first time but despite efforts stabilize state, diffraction data still reveal only core with no electron density...
Full-length BTK has been refractory to structural analysis. The nearest full-length structure of date consists the autoinhibited SH3-SH2-kinase core. Precisely how N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and proline-rich regions (PRR) contain linker) contribute regulation remains unclear. We have produced crystals for first time but despite efforts stabilize state, diffraction data still reveals only core with no electron density visible PHTH-PRR segment....
Full-length BTK has been refractory to structural analysis. The nearest full-length structure of date consists the autoinhibited SH3-SH2-kinase core. Precisely how N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and proline-rich regions (PRR) contain linker) contribute regulation remains unclear. We have produced crystals for first time but despite efforts stabilize state, diffraction data still reveals only core with no electron density visible PHTH-PRR segment....
Bruton's Tyrosine Kinase (BTK) is a nonreceptor tyrosine kinase that belongs to the TEC family. Mutations in