A5004253662- Machine Learning in Bioinformatics
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Plant Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Enzyme-mediated dye degradation
- CRISPR and Genetic Engineering
- Gut microbiota and health
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
Vilnius University
2022
Abstract Motivation Reliable prediction of protein thermostability from its sequence is valuable for both academic and industrial research. This problem can be tackled using machine learning by taking advantage the recent blossoming deep methods analysis. These facilitate training on more data and, possibly, enable development versatile predictors multiple ranges temperatures. Results We applied principle transfer to predict embeddings generated language models (pLMs) an input sequence. used...
Article21 October 2022Open Access Source DataTransparent process A new family of CRISPR-type V nucleases with C-rich PAM recognition Tomas Urbaitis CasZyme, Vilnius, Lithuania Institute Biotechnology, Vilnius University, Contribution: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - original draft, review & editing Search for more papers by this author Giedrius Gasiunas Corresponding Author [email protected]...
Abstract Motivation Reliable prediction of protein thermostability from its sequence is valuable for both academic and industrial research. This problem can be tackled using machine learning by taking advantage the recent blossoming deep methods analysis. These facilitate training on more data and, possibly, enable development versatile predictors multiple ranges temperatures. Results We applied principle transfer to predict embeddings generated language models (pLMs) an input sequence. used...
The formation of three oxidative DNA 5-methylcytosine (5mC) modifications (oxi-mCs)—5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC)—by the TET/JBP family dioxygenases prompted intensive studies their functional roles in mammalian cells. However, interplay these less abundant modified nucleotides other eukaryotic lineages remains poorly understood. We carried out a systematic study content distribution oxi-mCs RNA basidiomycetes Laccaria bicolor...