A5009736394- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Artificial Intelligence in Healthcare
- Cancer-related molecular mechanisms research
- Plant and Fungal Interactions Research
- Polyamine Metabolism and Applications
- Cancer-related gene regulation
- Gene expression and cancer classification
University of Toronto
2024
Columbia University
2024
Unlike coding genes, the number of lncRNA genes in organism genomes is relatively proportional to complexity. From plants humans, tissues with highest numbers and levels gene expression are male reproductive organs. To learn why, we initiated a genome-wide analysis Drosophila spatial patterns these tissues. The observed greatly exceed those previously reported, due largely preponderance non-polyadenylated transcripts. In stark contrast lncRNAs expressed post-meiotic spermatids. Correlations...
Polyamines are polycationic alkyl-amines abundant in proliferating stem and cancer cells. How these metabolites influence numerous cellular functions remains unclear. Here we show that polyamine levels decrease during differentiation inhibiting synthesis leads to a differentiated-like cell state. concentrate the nucleus further enriched nucleoli of cells culture