A5000093723- Organ Transplantation Techniques and Outcomes
- Bladder and Urothelial Cancer Treatments
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Ethics in Clinical Research
- Birth, Development, and Health
- Ovarian function and disorders
- Neuroendocrine regulation and behavior
- Estrogen and related hormone effects
- Transplantation: Methods and Outcomes
- Hormonal and reproductive studies
- Multiple and Secondary Primary Cancers
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Medical History and Innovations
- Cancer Treatment and Pharmacology
- Dialysis and Renal Disease Management
- Global Health and Surgery
- Per- and polyfluoroalkyl substances research
- LGBTQ Health, Identity, and Policy
- Lung Cancer Treatments and Mutations
- Synthesis and Biological Evaluation
- Public Health and Social Inequalities
- Anatomy and Medical Technology
Icahn School of Medicine at Mount Sinai
1980-2024
Mount Sinai Hospital
2024
Lenox Hill Hospital
2022
Northwell Health
2022
Mount Sinai Health System
2021
Institute of Cancer Research
2018-2020
Exalenz Bioscience (Israel)
2013
Novartis (Switzerland)
2013
Eli Lilly (United States)
2013
Roche (Switzerland)
2013
BackgroundUrothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer stage-for-stage prognosis than urothelial bladder. No international consensus exists on benefit adjuvant chemotherapy for patients UTUCs after nephroureterectomy curative intent. The POUT (Peri-Operative versus sUrveillance in Tract cancer) trial aimed to assess efficacy systemic platinum-based UTUCs.MethodsWe did a phase 3, open-label, randomised controlled at 71 hospitals UK. We recruited UTUC staged...
407 Background: The role of post nephro-ureterectomy (NU) treatment for UTUC is unclear. POUT (CRUK/11/027; NCT01993979) addresses whether adjuvant chemotherapy improves disease free survival (DFS) pts with histologically confirmed pT2-T4 N0-3 M0 UTUC. Methods: Pts (max n = 345) ≤90 days NU were randomised (1:1) to 4 cycles gemcitabine-cisplatin (gemcitabine-carboplatin if GFR 30-49ml/min) or surveillance subsequent required. had 6 monthly cross sectional imaging and cystoscopy the first 2...
The 24-h patterns of circulating cortisol and corticosterone were determined in male hamsters housed under a 14:10 light-dark cycle. Corticoid levels varied significantly over the sampling period with peak both hormones occurring near onset daily dark phase. ratio to changed dramatically during day. Corticosterone higher than early part light phase; however, became when began their rise. To examine whether circadian rhythm secretion could be involved physiological control hamster...
Background: Organ shortage remains a major challenge for the field of transplantation. Maximizing utilization and minimizing discard available organs is crucial to reduce waitlist times. Our aim was investigate landscape liver recovery, over past decade in United States, identify areas organ discard. Methods: This study used Scientific Registry Transplant Recipients Network Sharing database analyze rates associated reasons discarded from 2010 2021. All deceased donors were evaluated, data...
Abstract Race‐inclusive estimated glomerular filtration rate (eGFR) could contribute to racial disparity in access kidney transplantation. The Organ Procurement and Transplantation Network (OPTN) issued a policy allowing waiting time modification for candidates affected by race‐inclusive eGFR calculations. Implementation of the new OPTN at transplant program Mount Sinai Hospital involved review 921 African American candidates, whom 240 (26%) gained median 1 year 10 months. duration varied...
Testosterone concentrations in serum of rats bled throughout pregnancy and post partum were measured using Celite microcolumn chromatography a radioimmunoassay for testosterone. Mean levels testosterone ranged from about 170 to 340 pmol/l during the first 10 days pregnancy. Significant increases pregnant found on 12, 15 18 gestation. The highest occurred 20 when mean 3228 3685 respectively. declined before parturition day 22 (mean = 1449 further after 315 pmol/l). In order determine whether...
5α-DHP administered 24 or 48 hr post-PMSG treatment to 30-day-old prepuberal rats stimulated ovulation, as indicated by a greater number of eggs in the oviducts at 72 and higher percentage ovulating. 51 after gonadotropin stimulation caused inhibition ovulation similar action progesterone.
Abstract Background Normothermic machine perfusion (NMP) is a technique for donor liver preservation and assessment in transplantation. NMP has gained momentum recently by enabling safer use of higher risk organs via organ viability assessment. It also offers platform investigating ex vivo biology. Methods In this exploratory study, we completed complex vascular reconstruction explanted, diseased livers from patients undergoing transplantation then perfused them normothermically on closed...
Kidney transplantation is a life-saving intervention for end-stage renal disease; yet, the persistent gap between organ demand and supply remains significant challenge. This paper explores escalating discard rates of deceased donor kidneys in United States to assess trends, reasons, demographical differences, preservation techniques. Data from Scientific Registry Transplant Recipients 2010 2021 was analyzed using chi-squared tests trend significance logistic regression estimate odds ratios...
The authors evaluated the gonadotropin-testosterone-estradiol profiles of four homosexual men and heterosexual by a multiple-sampling technique. Although there was extensive overlap between two groups, subjects had higher estradiol levels than heterosexuals (70.3 +/- 19.8 versus 56.8 10.7 pg/ml) lower FSH values (5.1 1.0 13.2 3.4 mIU/ml). Testosterone luteinizing hormone were comparable in groups. These observations suggest that may be subtle differences gonadotropin secretion can detected...
Breast cancer is a diverse and varied disease. Recent research has shown that the collection of multiple biopsies before surgery can help researchers determine how responding to treatment predict for long-term outcomes. However be uncomfortable, sometimes clinicians teams in hospitals may reluctant offer clinical trials requiring several patients who have been recently diagnosed with breast cancer. The Institute Cancer Research Clinical Trials Statistics Unit (ICR-CTSU) oversees large number...
Abstract Background The utility of patient screening logs and their impact on improving trial recruitment rates are unclear. We conducted a retrospective exploratory analysis data collected within multicentre randomised controlled investigating chemotherapy for upper tract urothelial carcinoma. Methods Participating centres maintained record patients meeting basic criteria stipulated in the protocol, submitting regularly to clinical coordinating centre (CTC). Sites recorded number...