A5024542389- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Hematopoietic Stem Cell Transplantation
- Metabolism and Genetic Disorders
- Congenital Anomalies and Fetal Surgery
- Hepatitis C virus research
- Enhanced Recovery After Surgery
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Nutrition and Health in Aging
- Herpesvirus Infections and Treatments
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Soft tissue tumor case studies
Ewha Womans University
2025
Mount Sinai Hospital
2017-2024
Icahn School of Medicine at Mount Sinai
2017-2024
Mount Sinai Medical Center
2014-2023
Mount Sinai Health System
2022
Mount Sinai Hospital
2012-2021
Mount Sinai Hospital
2020
University of Miami
2002-2012
Miami Transplant Institute
2004-2012
Jackson Memorial Hospital
2005-2007
Ischemic cold storage (ICS) of livers for transplant is associated with serious posttransplant complications and underuse liver allografts.To determine whether portable normothermic machine perfusion preservation obtained from deceased donors using the Organ Care System (OCS) Liver ameliorates early allograft dysfunction (EAD) ischemic biliary (IBCs).This multicenter randomized clinical trial (International Randomized Trial to Evaluate Effectiveness Portable Preserving Assessing Donor Livers...
Candida auris is an urgent antimicrobial resistance threat due to its global emergence, high mortality, and persistent transmissions. Nearly half of C. clinical surveillance cases in the United States are from New York Jersey Metropolitan area.
In Brief Objective: The objective of this study was to summarize the evolution multivisceral transplantation over a decade experience and evaluate its current status. Summary Background Data: Multivisceral can be valuable for treatment patients with massive abdominal catastrophes. Its major limitations have been technical rejection intestinal graft. Methods: This consisted an outcome analysis 98 consecutive who received at our institution. represents largest single center date. Results: most...
Little is known about the long-term consequences of new-onset diabetes mellitus (NODM) after liver transplantation (LTX).In a chart review between 1996 and 2004, we evaluated its incidence possible effect on patient graft survival. Inclusion criteria were: adult primary LTX; deceased donor LTX without combined organs; dual immunosuppression with tacrolimus corticosteroid. Patients who died within six months were excluded. For analytical purposes, each was classified into one four groups: 1)...
In Brief Objective: To describe a single-center experience of pediatric intestinal transplantation (Itx) and to provide an overview the children who underwent this procedure along with their outcomes. Summary Background Data: Pediatric Itx presents multiple challenges because very young ages at which patients require higher susceptibility infectious complications. Methods: We have performed 141 in 123 median age 1.37 years. Primary grafts included isolated intestine (n = 28), liver 27),...
We investigated the role of donor bone marrow cell (DBMC) infusions in immunosuppression withdrawal adult liver transplantation. Patients enrolled were at least 3 years post-transplantation, with stable graft function. Forty-five (study group: G1) received DBMC, and 59 (control G2) did not. Immunosuppression was reduced by one third upon enrollment, another second year study completely withdrawn year. Patient survival similar between two groups. Although rejection episodes significantly less...
Background. Graft-versus-host-disease (GVHD) is a rare complication but carries high mortality after transplantation. We retrospectively evaluated the incidence, risk factors and impact of this on survival outcome intestinal transplantation at single center. Methods. 241 patients who underwent between March 1994 July 2007 were analyzed for evidence GVHD. A diagnosis GVHD was based clinical presentations confirmed by histological findings. Results. Of patients, 22 (9.1%) diagnosed as The...
Porto-caval hemitransposition (PCH) in liver transplantation allows revascularization of the when porto-mesenteric axis is thrombosed. We, here, review our experience over an 11-year period. A total 23 patients underwent using PCH. Immunosuppression was based on tacrolimus, with sirolimus used case renal insufficiency. Most common diagnoses were hepatitis C, Laennec's, Budd-Chiari and cryptogenic cirrhosis. Six needed splenectomy prior to transplant, 5 during 1 post-transplant, 11 had no...
Evaluation of the clinical impact including donor colon and ileocecal valve in patients receiving primary intestinal transplantation has not been performed a sufficiently large series cases.Cox stepwise regression overall cause-specific graft survival was to evaluate our single center cohort 245 consecutive transplant recipients, among which 93 received colon.Inclusion had no significant on either univariable (P=0.13) or multivariable (P=0.45) analysis, nor hazard rates death caused by...
Background. Donor-specific antibodies (DSA) are associated with acute kidney graft rejection, but their role in small bowel/multivisceral allograft remains unclear. We carried out a prospective study to understand the impact of DSA setting intestinal rejection. Methods. Thirteen patients (15 grafts) were serially evaluated for levels pre- and posttransplant. was determined by Luminex results interpreted as fluorescence intensity (FI), FI more than 3000 considered positive. Results. The...
Background: Organ shortage remains a major challenge for the field of transplantation. Maximizing utilization and minimizing discard available organs is crucial to reduce waitlist times. Our aim was investigate landscape liver recovery, over past decade in United States, identify areas organ discard. Methods: This study used Scientific Registry Transplant Recipients Network Sharing database analyze rates associated reasons discarded from 2010 2021. All deceased donors were evaluated, data...
The standard liver volume (LV) of a recipient is estimated in transplantation to determine the minimum LV necessary for recipient. Simple linear formulas estimation were developed Japanese and Caucasian populations. present study examined applicability reported Korean population. Liver density (LD) was determined by analyzing 24 healthy livers. Data weight (LW), body (BW), height (BH), surface area (BSA), age obtained from 652 postmortem examination reports (age, 42.4 ± 16.5 years) showing...
Due to the known high recurrence rate of hepatitis C virus (HCV) among orthotopic liver transplant (OLT) recipients who receive tacrolimus+corticosteroid maintenance, use steroid-free induction was considered.OLT with HCV were randomized tacrolimus+daclizumab (steroid-free) vs. tacrolimus+corticosteroids during 1999-2001 and then tacrolimus+mycophenolate mofetil (MMF)+daclizumab tacrolimus+MMF+corticosteroids 2002-2005. Patients in arm both periods received no steroids except for treating...
The threat of ischemic complications following massive resection, especially in living donor hepatectomy or split liver transplantation, has been haunting surgeons for many years. Postmortem dissections 62 livers were performed to investigate anatomical variations the principal artery segment 4 (A4). origin A4 was examined separately with (n = 46) without 16) an aberrant left hepatic (abLHA). A4s found be extrahepatic intrahepatic branches right (RHA), artery, proper and categorized into...
To describe the effect of splenic allograft in human multivisceral transplantation.We performed transplants spleen as part a graft an attempt to decrease both risk infection from asplenic state and rejection by possible tolerogenic effect. our knowledge, this is first report transplantation large series.All primary recipients who received donor (N = 60) were compared with those did not receive 81).Thirty-five 60 (58%) are alive group, 39 81 (48%) control group (P 0.98). In univariate...
Serum citrulline is a marker for acute cellular rejection (ACR) after intestinal transplantation; however, its clinical utility has not yet been established. The goal of this study was to determine clearcut serum levels beyond which the diagnosis could be supported or refuted, and predictors posttransplant from more accurate estimates sensitivity specificity obtained.Since March 2004, we obtained 2135 dried blood spot (DBS) samples 57 transplant recipients at 3 months posttransplant....
Background. Unlike other solid organs, no standardized treatment algorithms exist for intestinal transplantation (ITx). We established a consortium of American ITx centers to evaluate current practices. Methods. All performing during the past 3 y were invited participate. As consortium, we generated questions and collect data from each institution. The compiled analyzed. Results. Ten participated, 211 (range, 3–46; mean 21.1). Induction regimens varied widely. Thymoglobulin was most common,...
Survival after liver transplantation is negatively impacted by use of elderly deceased donors, but excluding them would increase waiting times and list mortality. We reviewed our experience with (LT) utilizing livers from donors 65 yr age older to identify those factors that impact graft survival. All adult patients (≥ 18 old) who underwent primary LT using donor aged ≥ between February 1995 November 2003 were included. With multivariate analysis we found four unfavorable characteristics...
This is a follow-up of withdrawal study that we previously performed on 104 liver transplant patients in which immunosuppression was gradually withdrawn over period 3 years. Eighty-one were not able to be (rejectors), and 23 successfully weaned off (tolerants).In this study, present their after the end study: compared results tolerant (n=23) with those rejectors (n=81). Follow-up until February 2010.Operational for an average 7.27±0.28 Patient survival rejector groups 63.66% 74.25%,...
Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and can be promoted by immunosuppressants. However, there no prevention or treatment for HCC after LT. Here we describe a clinical-scale method an adoptive immunotherapy approach that uses natural killer (NK) cells derived from deceased donor graft perfusate to prevent tumor Liver mononuclear (LMNCs) were extracted contained high percentage NK (45.0 ± 4.0%) compared...