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Contact & Profiles
A5116237066
Research Areas
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
George Mason University
2025
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent growth. Inhibition of the KRAS-RAF-MEK-ERK pathway enhances autophagic flux dependency, concurrent treatment with nonspecific autophagy inhibitor chloroquine (CQ) ERK-MAPK inhibitors can synergistically block PDAC However, CQ limited in terms specificity potency. To find alternative anti-autophagy strategies, here we performed a CRISPR-Cas9 loss-of-function screen cell lines that identified...
10.1158/0008-5472.can-24-1757
article
EN
Cancer Research
2025-02-11
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