A5092055771- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Yersinia bacterium, plague, ectoparasites research
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Bacterial Genetics and Biotechnology
- Supramolecular Self-Assembly in Materials
- Bacillus and Francisella bacterial research
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
University of Oslo
2023-2025
The formation of phase separated membrane domains is believed to be essential for the function cell. precise composition and physical properties lipid bilayer play crucial roles in regulating protein activity governing cellular processes. Perturbation domain structure human cells can related neurodegenerative diseases cancer. Lipid rafts are also bacteria, potentially serving as targets antibiotics. An important question how affected by bioactive therapeutic molecules, such surface-active...
Peptide-lipid interactions play an important role in defining the mode of action drugs and molecular mechanism associated with many diseases. Model membranes consisting simple lipid mixtures mimicking real cell can provide insight into structural dynamic aspects these interactions. Small-angle scattering techniques based on X-rays neutrons (SAXS/SANS) allow situ determination peptide partition changes bilayers vesicles relatively high resolution between 1-100 nm. With advanced...
Antimicrobial peptides (AMPs) are highly effective broad-spectrum antibiotics, found as components of the immune system in almost all forms life. It is well established that their primary target cell membrane where they hypothesized to permeabilize bilayer. However, it a long-standing question whether stable transmembrane and structural pores necessary, or if through transient channels. Here this addressed with simultaneous characterization structure, peptide partitioning, ion transport real...
Poly-proline II helices are secondary structure motifs frequently found in ligand-binding sites. They exhibit increased flexibility and solvent exposure compared to the strongly hydrogen-bonded α-helices or β-strands can therefore easily be misinterpreted as completely unstructured regions with an extremely high rotational freedom. Here, we show that adhesin YadA of Yersinia enterocolitica serotype O:9 contains a poly-proline helix interaction motif N-terminal region. The is involved