A5013580576- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related gene regulation
- RNA regulation and disease
- Wnt/β-catenin signaling in development and cancer
- Cerebral Palsy and Movement Disorders
- Endoplasmic Reticulum Stress and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Renal function and acid-base balance
- Balance, Gait, and Falls Prevention
- Total Knee Arthroplasty Outcomes
- Pluripotent Stem Cells Research
- Knee injuries and reconstruction techniques
- Polyamine Metabolism and Applications
Indiana University – Purdue University Indianapolis
2024
Western University
2021
University of Liverpool
2015-2020
StemCells (United States)
2017-2020
University of Bristol
2013-2016
Meniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of meniscus where current repair techniques usually fail. We described previously use undifferentiated autologous mesenchymal stem cells (MSCs) seeded onto a collagen scaffold (MSC/collagen-scaffold) integrate meniscal tissues vitro. Our objective was translate this method into cell therapy for patients with torn meniscus, long-term goal delaying or preventing onset OA. After vitro...
Multipotent mesenchymal stem cells (MSCs) have enormous potential in tissue engineering and regenerative medicine. However, until now, their development for clinical use has been severely limited as they are a mixed population of with varying capacities lineage differentiation formation. Here, we identify receptor tyrosine kinase-like orphan 2 (ROR2) cell surface marker expressed by those MSCs an enhanced capacity cartilage We generated clonal human MSC populations chondrogenesis. ROR2 was...
Cartilage injuries and osteoarthritis are leading causes of disability in developed countries. The regeneration damaged articular cartilage using cell transplantation or tissue engineering holds much promise but requires the identification an appropriate source with a high proliferative propensity consistent chondrogenic capacity. Human fetal mesenchymal stem cells (MSCs) have been isolated from range perinatal tissues, including first-trimester bone marrow, demonstrated enhanced expansion...
Mesenchymal stem cells (MSCs) have been investigated as a potential injectable therapy for the treatment of knee osteoarthritis, with some evidence success in preliminary human trials. However, optimization and scale-up this therapeutic approach depends on identification functional markers that are linked to their mechanism action. One possible is through chondrogenic differentiation direct role neo-cartilage synthesis. Alternatively, they could remain undifferentiated act release trophic...
Chondrogenic progenitor populations, including mesenchymal stem cells, represent promising cell-based transplantation or tissue engineering therapies for the regeneration of damaged cartilage. Osteoarthritis (OA) predominantly affects elderly and is a leading cause disability worldwide. Advancing age prominent risk factor that closely associated with onset progression disease. Understanding influence aging OA have on chondrogenic cells important to determine how these processes affect...
Cancers invoke various pathways to mitigate external and internal stresses continue their growth progression. We previously reported that the eIF2 kinase GCN2 integrated stress response are constitutively active in prostate cancer (PCa) required maintain amino acid homeostasis needed fuel tumor growth. However, although loss of function reduces intracellular availability PCa growth, there is no appreciable cell death. Here, we discovered induces prosenescent p53 signaling. This activation...