A5062475671- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Catalysis for Biomass Conversion
- Catalysis and Hydrodesulfurization Studies
- Biodiesel Production and Applications
- Cellular transport and secretion
- Retinal Development and Disorders
- Neurobiology and Insect Physiology Research
- Cardiac electrophysiology and arrhythmias
Leipzig University
2023
University of Utah
2021
SRM Institute of Science and Technology
2020
Abstract Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities homeostasis often leads electrical contractile dysfunction can cause dilated cardiomyopathy heart failure. However, the specific of VDAC2 intracellular dynamics cardiac function not well understood. To elucidate homeostasis, we generated ventricular myocyte-specific developmental deletion Vdac2 mice. Our results...
SUMMARY Presynaptic forms of plasticity occur throughout the nervous system and play an important role in learning memory but underlying molecular mechanisms are insufficiently understood. Here we show that small GTPase Rab3 is a key mediator cyclic AMP (cAMP)-induced presynaptic Drosophila . Pharmacological optogenetic cAMP production triggered concentration-dependent alterations synaptic transmission, including potentiation depression evoked neurotransmitter release, as well strongly...