A5007697646- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Synthesis and Catalytic Reactions
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Advanced machining processes and optimization
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Advanced Machining and Optimization Techniques
- Adenosine and Purinergic Signaling
- Additive Manufacturing Materials and Processes
- Immune Cell Function and Interaction
- CAR-T cell therapy research
Georgetown University
2023-2025
Georgetown University Medical Center
2023-2025
Vince Lombardi Cancer Clinic
2023-2024
Georgetown Lombardi Comprehensive Cancer Center
2023
China National Heavy Duty Truck Group (China)
2022
Cancer cells can overexpress CD47, an innate immune checkpoint that prevents phagocytosis upon interaction with signal regulatory protein alpha (SIRPα) expressed in macrophages and other myeloid cells. Several clinical trials have reported CD47 blockade reduces tumor growth hematological malignancies. However, has shown modest results solid tumors, including melanoma. Our group demonstrated histone deacetylase 6 inhibitors (HDAC6is) immunomodulatory properties, such as controlling macrophage...
Prostate cancer (PCa) ranks as the second leading cause of cancer-related deaths among men in United States. Prostate-specific membrane antigen (PSMA) represents a well-established biomarker PCa, and its levels correlate positively with disease progression, culminating at stage metastatic castration-resistant prostate cancer. Due to tissue-specific expression cell surface localization, PSMA shows superior potential for precise imaging therapy PCa. Antibody-based immunotherapy targeting...
Abstract Radiotherapy is a curative cancer treatment modality that imparts damage to cellular DNA, induces immunogenic cell death, and activates antitumor immunity. Despite the radiotherapy-induced direct effect seen within treated volume, accumulating evidence indicates activation of innate Acute proinflammatory responses mediated by anticancer M1 macrophages are observed in immediate aftermath following radiotherapy. However, after few days, these converted anti-inflammatory pro-cancer M2...
Abstract Introduction: Aging of the immune system is a critical risk factor for chronic diseases, including cancer. Globally, cancer incidence higher between 45 to 75 years age and declines thereafter. However, implications aging in are understudied, aged populations underrepresented, both preclinical clinical studies. The role macrophages progression has gained attention as tool target anticancer therapies. Tumor-associated (TAMs) mainly exhibit an anti-inflammatory M2 phenotype, promote...
Abstract The interplay between tumor cells and immune within the microenvironment (TME) dictates protumor or antitumor responses. Tumor-associated macrophages (TAMs) respond to signals of TME exhibit a spectrum phenotypes ranging M1 (antitumor) M2 (protumor) macrophages. In most types, including melanoma, balance is critical with higher M1/M2 ratio favoring immunity. Therefore, strategies enhancing can significantly alter towards this study, we administered luciferase GFP-expressing as an...
Abstract Histone Deacetylases (HDACs) are enzymes that modify histones and non-histone proteins. Our group has previously demonstrated HDAC6 inhibitors (HDAC6is) modulate multiple immune pathways, including those suppress the antitumoral M2 phenotype, leading to improved antitumor immunity. Despite potential of HDAC6is, current have poor selectivity off-target effects only work at micromolar concentrations. In this work, we designed a screening pipeline HDAC6i, considering selectivity,...
Abstract Patients with advanced melanoma are often treated radiation therapy (RT) in combination immunotherapies. Immunogenic tumor cell death induced by is known to activate innate and adaptive immunity. Macrophage activity the irradiated microenvironment (TME) has been implicated play a critical role post-RT immune responses. However, tumor-associated macrophages (TAMs) due their phenotypic plasticity convert from initial antitumor M1 phenotype protumor M2 resulting relapse metastasis of...
Abstract Introduction: Pan-histone deacetylase (HDAC) inhibitors have been used as anti-cancer agents due to their cytotoxicity. However, studies from our group reported that intervention of class-specific HDAC can differentially affect immune-related pathways in macrophages and influence pro- or anti-inflammatory phenotype function. For example, specific HDAC6 demonstrated promising anti-tumor effects by suppressing tumor-promoting M2 the tumor microenvironment (TME). In contrast,...
Abstract The cluster of differentiation 47(CD47) is a ubiquitously expressed innate immune checkpoint transmembrane protein but often overexpressed in cancer cells. CD47 interacts with signal regulatory alpha (SIRPα) on macrophages leading to tyrosine phosphatase activation and preventing myosin accumulation at the phagocytic synapse. SIRPa triggers “Do not eat me” signal, negatively regulating phagocytosis macrophages. Blockade CD47-SIRPα novel immunotherapeutic approach enhance antitumor...
<p>Supplementary Figure 6 A_B</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Data Figure Legend</p>
<p>Supplementary Figure 1</p>
<div>Abstract<p>Radiotherapy is a curative cancer treatment modality that imparts damage to cellular DNA, induces immunogenic cell death, and activates antitumor immunity. Despite the radiotherapy-induced direct effect seen within treated volume, accumulating evidence indicates activation of innate Acute proinflammatory responses mediated by anticancer M1 macrophages are observed in immediate aftermath following radiotherapy. However, after few days, these converted...
<p>Supplementary Figure 4</p>
<p>Supplementary Figure 6 C_D</p>
<div>Abstract<p>Radiotherapy is a curative cancer treatment modality that imparts damage to cellular DNA, induces immunogenic cell death, and activates antitumor immunity. Despite the radiotherapy-induced direct effect seen within treated volume, accumulating evidence indicates activation of innate Acute proinflammatory responses mediated by anticancer M1 macrophages are observed in immediate aftermath following radiotherapy. However, after few days, these converted...
<p>Supplementary Figure 6 A_B</p>
<p>Supplementary Figure 5</p>
<p>Supplementary Figure 2</p>
<p>Supplementary Data Figure Legend</p>
<p>Supplementary Figure 3</p>
<p>Supplementary Figure 3</p>