About
Contact & Profiles
A5103216995
Research Areas
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
National Cancer Institute
2022
National Human Genome Research Institute
2022
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source this endogenous damage remains unclear. Using two systems postmitotic lineage specification-induced pluripotent stem cell-derived neurons and transdifferentiated macrophages-we show thymidine glycosylase (TDG)-driven excision methylcytosines oxidized with ten-eleven translocation enzymes (TET) is a SSBs. Although macrophage differentiation favors short-patch base repair fill...
10.1126/science.add9838
article
EN
Science
2022-12-01
Coming Soon ...