A5068717263- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Vitamin C and Antioxidants Research
- Pneumocystis jirovecii pneumonia detection and treatment
- vaccines and immunoinformatics approaches
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Pneumonia and Respiratory Infections
- Orthopedic Infections and Treatments
- Infectious Diseases and Mycology
Colorado State University
2024
Center for Discovery
2022-2023
Hackensack Meridian Health
2022-2023
UK Health Security Agency
2022
Public Health England
2017-2020
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a potentially fatal infectious requiring long treatment duration with multiple antibiotics and against which there no reliable cure. Among the factors that have hampered development of adequate drug regimens lack an animal model reproduces NTM lung pathology required for studying antibiotic penetration efficacy. Given documented similarities between tuberculosis immunopathology in patients, we first determined rabbit active key...
The need for an effective vaccine against human tuberculosis has driven the development of different candidates and vaccination strategies. Novel live attenuated vaccines are being developed that promise greater safety efficacy than BCG tuberculosis. We combined with MTBVAC to evaluate whether either would be affected upon revaccination. In a well-established guinea pig model aerosol infection Mycobacterium tuberculosis, delivered via various prime-boost combinations or alone were compared....
The control of bacterial growth is key to the prevention and treatment tuberculosis (TB). Granulomas represent independent foci host immune response that present heterogeneous capacity for growth. At whole tissue level, B cells CD4 or CD8 T have an established role in protection against TB. Immune interact within each granuloma response, but impact composition on replication remains unknown. Here we investigate associations between cell composition, including cell, CD4, cells, state...
Abstract Bovine tuberculosis (BTB) caused by Mycobacterium bovis remains a major problem in both the developed and developing countries. Control of BTB UK is carried out test slaughter infected animals, based primarily on tuberculin skin (PPD). Vaccination with attenuated strain M. pathogen, BCG, not used to control bovine cattle at present, due its variable efficacy because it interferes PPD test. Diagnostic tests capable Differentiating Infected from Vaccinated Animals (DIVA) have been...
Tuberculosis remains a major health threat globally and more effective vaccine than the current Bacillus Calmette Guerin (BCG) is required, either to replace or boost it. The Spore-FP1 mucosal candidate based on fusion protein of Ag85B-Acr-HBHA/heparin-binding domain, adsorbed surface inactivated subtilis spores. conferred significant protection against Mycobacterium. tuberculosis challenge in naïve guinea pigs markedly improved lungs spleens animals primed with BCG. We then immunized rhesus...
A global BCG vaccine shortage began in 2013 which impacted availability for infant vaccinations, as well preclinical studies and clinical trials of new TB vaccines. Stakeholders met 2015 at McGill University Montreal to discuss the potential mitigation strategies. Manufacturing through a more tractable liquid fermentation process instead traditional pellicle growth method was considered potentially viable strategy. This pilot program compared pellicle-grown shake flask-grown strains (as...
Tuberculosis meningitis (TBM) is essentially treated with the first-line regimen used against pulmonary tuberculosis, a prolonged continuation phase. However, clinical outcomes are poor in comparison, for reasons that only partially understood, highlighting need improved preclinical tools to measure drug distribution and activity at site of disease. A predictive animal model TBM would also be great value prioritize promising regimens tested trials, given healthy state development pipeline...
Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for evaluation drug efficacy against tuberculosis (TB). Firstly, pharmacokinetics (PK) each drugs Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) and Ethambutol (E), that are standardly used treatment tuberculosis, was established blood macaques after oral dosing as a monotherapy or combination. Two conducted evaluate pharmacodynamics different combinations using...