A5067825765- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Silk-based biomaterials and applications
- HIV Research and Treatment
- Electrohydrodynamics and Fluid Dynamics
- Hemostasis and retained surgical items
- Dendrimers and Hyperbranched Polymers
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Conducting polymers and applications
- Pharmacological Effects and Toxicity Studies
- Neurological Complications and Syndromes
- Nanoparticles: synthesis and applications
- Adenosine and Purinergic Signaling
- Endoplasmic Reticulum Stress and Disease
- Advanced Drug Delivery Systems
University of Toronto
2024-2025
University of Shanghai for Science and Technology
2022-2024
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded active ingredients for providing functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed polycaprolactone fenoprofen core working fluid, different types unspinnable fluids (including pure solvent,...
The poor solubility of numerous drugs pose a long-existing challenge to the researchers in fields pharmaceutics, bioengineering and biotechnology. Many "top-down" "bottom-up" nano fabrication methods have been exploited provide solutions for this issue. In study, combination strategy top-down process (electrospinning) bottom-up (self-emulsifying) was demonstrated be useful enhancing dissolution typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone...
Abstract Dolutegravir (DTG)‐based antiretroviral therapy is the contemporary first‐line to treat HIV infection. Despite its efficacy, mounting evidence has suggested a higher risk of neuropsychiatric adverse effect (NPAE) associated with DTG use, limited understanding underlying mechanisms. Our laboratory previously reported toxic but not bictegravir (BTG) in disrupting blood–brain barrier (BBB) integrity. The current study aimed investigate mechanism toxicity. Primary cultures mouse brain...
Abstract Integrase strand transfer inhibitors (INSTIs) based antiretroviral therapy (ART) is currently used as first‐line regimen to treat HIV infection. Despite its high efficacy and barrier resistance, ART‐associated neuropsychiatric adverse effects remain a major concern. Recent studies have identified potential interaction between the INSTI, dolutegravir (DTG), folate transport pathways at placental barrier. We hypothesized that such interactions could also occur two blood–brain...
The nanofibers formed by electrospinning technology have the advantages of orderly release mechanism and controllable dissolution rate. However, use toxic harmful organic solvents is widespread in field electrospinning, which not only poses a potential hazard to human health natural environment, but also increases manufacturing cost difficulty electrospinning. Therefore, purpose this paper introduce application green food engineering. Water solvent mainly introduced, some water-soluble...