A5060653168- Click Chemistry and Applications
- Biotin and Related Studies
- Synthesis of Indole Derivatives
- Antimicrobial Peptides and Activities
- Protein Tyrosine Phosphatases
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Effects and risks of endocrine disrupting chemicals
- S100 Proteins and Annexins
- bioluminescence and chemiluminescence research
Beijing National Laboratory for Molecular Sciences
2024-2025
Peking University
2010-2025
Center for Life Sciences
2024-2025
King Center
2025
Immunotherapy efficacy in solid tumors varies greatly, influenced by the tumor microenvironment (TME) and dynamic tumor-immune interactions within it. Decoding these situ with minimal interference native tissue architecture delicate immune responses is critical for understanding progression optimizing therapeutic strategies. Here, we introduce CAT-Tissue, a novel deep-red photocatalytic proximity labeling method that enables ultrafast, high-resolution profiling of primary tissues. By...
A tunneling nanotube (TNT) is a newly discovered structure involved in cell–cell communication and found various types of cells. Here we identify S100A4 as an extracellular molecule describe its role attracting the growth direction TNTs. Together with putative receptor, receptor for advanced glycation end product, demonstrate their involvement TNT guidance. Our results further suggest mechanism guidance In TNT-initiating cells, p53 activates caspase-3, which leads to cleavage subsequent...
Effective antitumor immunity hinges on the specific engagement between tumor and cytotoxic immune cells, especially T cells. Although investigating these intercellular interactions is crucial for characterizing responses guiding immunotherapeutic applications, direct quantitative detection of tumor–T cell within a live-cell context remains challenging. We herein report photocatalytic interaction labeling strategy (CAT-Cell) relying bioorthogonal decaging quinone methide moieties sensitive...
Background/Objectives: Bisphenol A (BPA) is a pervasive environmental endocrine disruptor, and the lifestyle associated with high-fat diet becoming increasingly common. The precise relationship between these factors high incidence of insulin resistance type 2 diabetes worldwide in recent years remains unclear. Given critical role skeletal muscle maintaining systemic glucose metabolism, this study aimed to explore potential effects co-exposure BPA on signaling molecules GLUT4 translocation...