A5058384395- Nutrition and Health in Aging
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Heart Failure Treatment and Management
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Hip and Femur Fractures
- Chronic Disease Management Strategies
- Parathyroid Disorders and Treatments
- Dysphagia Assessment and Management
- HIV-related health complications and treatments
- GDF15 and Related Biomarkers
- Cardiac Health and Mental Health
- Muscle metabolism and nutrition
- Health disparities and outcomes
- Obesity and Health Practices
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Erythropoietin and Anemia Treatment
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
Sapporo Medical University
2022-2024
Sapporo Medical University Hospital
2021-2024
Abstract Aims Reduction in appendicular skeletal muscle mass index (ASMI) assessed by dual‐energy X‐ray absorptiometry (DEXA) has been shown to be independently associated with a higher mortality rate patients heart failure (HF). However, DEXA is not suitable for measurement of daily clinical setting and large population‐based studies. The aim this study was determine whether ASMI predicted from anthropometric indicators (predicted ASMI) serves as an alternative DEXA‐measured predicting...
Abstract Aims Elevated plasma branched‐chain amino acids (BCAAs) are tightly linked to incident diabetes and its complications, while lower BCAAs associated with adverse outcomes in the elderly heart failure (HF) patients. The interplay between body compositions BCAAs, especially under influence of co‐morbid HF patients, is not well understood. Here, we examined impact on prognostic value BCAA association Methods results We retrospectively 301 patients (70 ± 15 years old; 59% male), among...
Although the impact of physical frailty on prognosis and effect cardiac rehabilitation in HF patients has been well established, data for prognostic social (SF) are limited. In addition, relative importance each SF domain clinical outcomes remains unclear. We aimed to get a new insight into associations with elderly hospitalized patients.A single-center, retrospective cohort study was conducted using from 310 in-hospital aged ≥ 65 years (mean age 78 ± 8 years; 49% women). Makizako's five...
The mechanism by which a sodium-glucose cotransporter inhibitor (SGLT2i) induces favorable effects on diabetes and cardiovascular diseases including heart failure (HF) remains poorly understood. Metabolomics amino acid profiling enables detection of alterations in whole body metabolism. aim this study was to determine whether plasma profiles are modulated SGLT2i use HF patients with type 2 mellitus (T2DM).
Background: The renin-angiotensin system (RAS) activation is a proposed mechanism of muscle wasting (MW i.e., reduction in mass). Although we reported that RAS inhibitors (RASIs) were associated with lower prevalence MW heart failure (HF) patients, the relationship between mineralocorticoid receptor (MR) signaling and has not been analyzed.
Aim We examined whether the addition of self‐reported weight loss improves accuracy prediction mortality caused by sarcopenia in heart failure (HF) patients. Methods enrolled 477 HF patients (mean age 77 years) who received combined assessment and loss. Sarcopenia was diagnosed according to criteria Asian Working Group for Sarcopenia. If answered “yes” question “have you lost 2 kg or more past 6 months?”, they were as having Results coexisted 32% During a median follow‐up period 763 days, 65...
The adverse effects of low daily protein intake (DPI) on clinical outcomes in patients with heart failure (HF) are known; however, an optimal DPI to predict event remains undetermined. Moreover, whether restriction therapy for chronic kidney disease is applicable HF and renal dysfunction unclear.
Iron deficiency (ID) is common in patients with heart failure (HF) and reportedly associated exercise intolerance impaired quality of life. supplementation therapy HF ID improves capacity. Conversely, protective roles iron depletion the development diabetes mellitus (DM) its complications have been proposed. This study aimed to determine impact on physical function without DM.
Background: A multidisciplinary team (MDT) approach is crucial for managing older patients with heart failure (HF). We investigated the impact on clinical outcomes of implementation a conference sheet (CS) an 8-component radar chart visualizing and sharing patient information.
Background: Evaluation of sarcopenia requires quantifying appendicular skeletal muscle mass and functional capacity, but resource constraints often limit feasibility. Alterations in quality, especially intramuscular lipid infiltration (i.e., myosteatosis), systemic metabolic derangements are associated with disability. Hypothesis: Opportunistic CT imaging plasma amino acid profiling could identify low physical function patients heart failure (HF). Methods: We retrospectively examined 220 HF...
The utility of the updated Asian Working Group for Sarcopenia (AWGS) criteria in diagnosing sarcopenia older patients with heart failure (HF) remains unclear.
Abstract Funding Acknowledgements Type of funding sources: None. Background Skeletal muscle mass in heart failure (HF) patients is closely related to exercise tolerance and prognosis. Although the dual-energy X-ray absorptiometry (DEXA) method a standard for measuring skeletal mass, it not suitable daily clinical setting since costly hospital-based modality. We recently reported that an equation appendicular index (ASMI) estimation using anthropometric parameters predicted DEXA-measured ASMI...
Abstract Background Accurate prediction of mortality in heart failure (HF) patients is crucial for decision-making regarding HF therapies, but a strategy the elderly has not been established. In addition, although favorable effects comprehensive cardiac rehabilitation (CR) on clinical outcomes and functional status have demonstrated, goal CR during hospitalization reducing remains unclear. Aims We examined whether assessment basic activities daily living (ADL) by Barthel Index (BI), most...
Osteoporosis is prevalent and associated with poor prognosis in patients heart failure (HF). However, bone mineral density measurement by a dual-energy X-ray absorptiometry (DEXA) scan not always available daily clinical setting or large-scale population-based studies.
Abstract Funding Acknowledgements Type of funding sources: None. Introduction Sarcopenia is associated with poor functional status and clinical outcomes in heart failure (HF) patients. Although recent observational studies showed the relationship between lower serum vitamin D levels development physical function community-dwelling older adults, involvement sarcopenia HF patients remain unclear. This study aimed to investigate impact concentrations on HF. Methods We retrospectively enrolled...
Abstract Background Frailty is a complex syndrome characterized by decline in functional reserve, and associated with aging chronic diseases including heart failure (HF). The impact of physical frailty on prognosis the effect cardiac rehabilitation HF patients have been well established. However, data prognostic social (SF) limited. Aims We aimed to get new insight into mechanisms association SF clinical outcomes older hospitalized patients. Methods A single-center, retrospective cohort...
Abstract Background Sarcopenia, the loss of muscle mass and function, osteoporosis, a condition low bone micro-architectural deterioration bone, frequently coexist are associated with functional status in heart failure (HF) patients. Aims We aimed to investigate impact coexistence sarcopenia osteoporosis on HF Methods This cross-sectional study was conducted using data from patients who admitted our institute for diagnosis management 1 November 2015 30 April 2021. All received dual-energy...