About
Contact & Profiles
A5082288212
Research Areas
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- DNA Repair Mechanisms
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated double strand break repair, has been proposed as an attractive target the treatment of BRCA deficient and other repair pathway defective cancers. As previously reported, we recently identified first selective small molecule Polθ in vitro probe, 22 (ART558), recapitulates phenotype loss, vivo 43 (ART812), efficacious a model PARP inhibitor resistant TNBC vivo. Here describe discovery, biochemical biophysical...
10.1021/acs.jmedchem.2c01142
article
EN
Journal of Medicinal Chemistry
2022-10-06
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