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Christel Elkhoury Youhanna

ORCID: 0009-0003-0411-0258
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About
Contact & Profiles
A5093684334
Research Areas
  • Single-cell and spatial transcriptomics
  • Genomics and Chromatin Dynamics
  • Molecular Biology Techniques and Applications
  • Ubiquitin and proteasome pathways

Biologie Intégrative des Organismes Marins
 2024

 Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software
OPENALEX - Publications 
Jean-Bernard Fiche Marie Schaeffer Christophe Houbron Christel Elkhoury Youhanna Olivier Messina and 2 more Franziska Barho Marcelo Nöllmann

10.1007/978-1-0716-3766-1_16 article EN Methods in molecular biology 2024-01-01
 Chromatin folding motifs define the basic grammar of TAD architecture in single alleles
OPENALEX - Publications 
Olivier Messina Jean-Bernard Fiche Christel Elkhoury Youhanna Gautham Ganesh Yasmine Kemkem and 5 more Alexandre Mesnager İldem Akerman David Hodson Marie Schaeffer Marcelo Nöllmann

Chromatin structure varies dramatically among single cells, yet the specific motifs underpinning this organization remain poorly understood. Using imaging-based spatial genomics, we visualized 3D chromatin across seven mouse tissues. We demonstrate that traces can be decomposed into loop and domain Folding Motifs (CFMs). Polymer simulations revealed loop-extrusion reproduces CFMs, while cis-regulatory interactions are primarily responsible for CFMs. Notably, a unique set of CFMs describes...

10.1101/2024.09.18.613689 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-09-19
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