A5093131846- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Rabies epidemiology and control
- Protease and Inhibitor Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Ultrasound and Hyperthermia Applications
- Angiogenesis and VEGF in Cancer
- Cardiac Fibrosis and Remodeling
- Pulmonary Hypertension Research and Treatments
- Pneumonia and Respiratory Infections
- Neuropeptides and Animal Physiology
- Streptococcal Infections and Treatments
- Axon Guidance and Neuronal Signaling
- Neonatal Health and Biochemistry
- Renin-Angiotensin System Studies
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
University of Colorado Denver
2023-2025
University of Colorado Anschutz Medical Campus
2024
University of Northern Colorado
2024
Denver Health Medical Center
2024
Health and Hospital Corporation
2024
Consejo Superior de Investigaciones Científicas
2024
The University of Texas at Arlington
2024
University of Tübingen
2024
Liverpool School of Tropical Medicine
2024
University of California, Riverside
2024
Abstract Aims Following myocardial infarction (MI), the heart repairs itself via a fibrotic repair response. The degree of fibrosis is determined by balance between deposition extracellular matrix (ECM) activated fibroblasts and breakdown nascent scar tissue proteases that are secreted predominantly inflammatory cells. Excessive proteolytic activity turnover has been observed in human failure, protease inhibitors injured regulate breakdown. Serine (Serpins) represent largest most...
Pulmonary hypertension (PH) is a progressive vascular disease characterized by remodeling, stiffening, and luminal obstruction, driven dysregulated cell proliferation, inflammation, extracellular matrix (ECM) alterations. Despite the recognized contribution of ECM dysregulation to PH pathogenesis, precise molecular alterations in matrisome remain poorly understood. In this study, we employed matrisome-focused proteomics approach map protein composition young bovine calf model acute...
Abstract Identification and characterization of snake venom toxins that interfere with hemostasis have important implications for the treatment envenomation, bioprospecting therapeutically useful molecules, development research tools investigating hematologic disorders. Many venoms been shown to possess thrombolytic activity. However, it remains unclear if actions on other clot-stabilizing proteins beyond fibrin chains contribute significantly venom-induced thrombolysis because clot-wide...
Recently developed
Streptococcus pneumoniae (S. pneumoniae) employs various metabolic pathways to generate nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for redox balance, fatty acid synthesis, and energy production. GAPN, a non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, plays role in this process by directly reducing NADP
Abstract New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address problem snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization medically significant toxins in vivo and vitro . The development high-throughput approaches for screening such could accelerate their identification, testing, implementation, thus holds exciting potential improving outcomes envenomation worldwide. Energetics-based...