A5084650670- Laser Applications in Dentistry and Medicine
- Cell Adhesion Molecules Research
- Medical and Biological Ozone Research
- Photodynamic Therapy Research Studies
- Liver Disease Diagnosis and Treatment
- Cell Image Analysis Techniques
- Apelin-related biomedical research
- Advanced Fluorescence Microscopy Techniques
- Nitric Oxide and Endothelin Effects
- Diet and metabolism studies
- Laser-Ablation Synthesis of Nanoparticles
- Ocular and Laser Science Research
- Nanoplatforms for cancer theranostics
Leibniz Institute for Neurobiology
2025
Bayer (Germany)
2024
University of Tübingen
2022-2024
Massachusetts General Hospital
2022-2024
Harvard University
2024
The current management of patients with stroke intravenous thrombolysis and endovascular thrombectomy is effective only when it timely performed on an appropriately selected but minor fraction patients. development novel adjunctive therapy highly desired to reduce morbidity mortality stroke. Since endothelial dysfunction implicated in the pathogenesis featured suppressed nitric oxide synthase (eNOS) concomitant deficiency, restoring represents a promising approach treating injury.
There is solid evidence of the beneficial effect photobiomodulation (PBM) with low-power near-infrared (NIR) light in NIR-I window increasing bioavailable nitric oxide (NO). However, it not established whether this can be extended to NIR-II light, limiting broader applications therapeutic modality. Since we have demonstrated PBM NIR laser window, determined causal relationship between irradiation and its specific biological effects on NO bioavailability. We analyzed impact release cultured...
<title>Abstract</title> Selective plane illumination microscopy (SPIM, also known as light sheet fluorescence microscopy) is the method of choice for studying organ morphogenesis and function, it permits gentle rapid volumetric imaging biological specimens over days. In inhomogeneous samples, however, sample-induced aberrations, including absorption, scattering, refraction, can degrade image, particularly focal gets deeper into sample. Here, we present Leonardo, first toolbox capable...
Immunotherapy, including immune checkpoint inhibitors, has revolutionized cancer treatment, but only a minor fraction of patients shows durable responses. A new approach to overcome this limitation is yet be identified. Recently, we have shown that photobiomodulation (PBM) with near-infrared (NIR) light in the NIR-II window reduces oxidative stress and supports proliferation CD8+ T cells, suggesting PBM could augment anti-cancer immunity. Here, report novel support tumor-infiltrating cells...
<p class="first" dir="auto" id="d1332678e174">Metabolic dysfunction-associated steatotic liver disease encompasses a spectrum of chronic diseases ranging from steatosis to metabolic steatohepatitis (MASH). Hepatic stellate cells (HSCs), the pericytes liver, have been associated with pathogenesis MASH. In diseased livers, HSCs transdifferentiate into αSMA+ myofibroblasts. this activated stage, they produce excess collagen as well proinflammatory and profibrogenic cytokines. are known express...
<p class="first" dir="auto" id="d1262079e139">Rupture of unstable atherosclerotic plaques can lead to heart attack and stroke. Smooth muscle cells (SMCs) generate extracellular matrix (ECM) that contributes plaque stability. Phenotypic switching SMCs during atherogenesis may influence ECM composition stability plaques. cGMP signaling modulates SMC growth phenotype, but how the affects this process in lesions is not well understood. Fibronectin (Fn1) an abundant component has been linked...
<p class="first" dir="auto" id="d15870589e162">Hypertension is an important risk factor for the development of vascular diseases. NO/NO-sensitive guanylyl cyclase (NO-GC)/cGMP signaling, a major mechanism vasodilatation, affects blood pressure by regulating relaxation smooth muscle cells (VSMCs). Under (patho-)physiological conditions, VSMCs are exposed to mechanical forces such as shear stress and stretch. Based on our recent discovery mechanosensitive NO/cGMP signaling in platelets, we...