A5073954854- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Diverse Scientific Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Pharmaceutical studies and practices
- Cardiac electrophysiology and arrhythmias
- HIV/AIDS drug development and treatment
- COVID-19 Prevention and Impact
- Pneumonia and Respiratory Infections
- Growth Hormone and Insulin-like Growth Factors
- Mycobacterium research and diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Antimicrobial Resistance in Staphylococcus
- Ion channel regulation and function
- Diagnosis and treatment of tuberculosis
Tashkent Pediatric Medical Institute
2021-2024
ABSTRACT Regimens for the treatment of rifampicin-resistant tuberculosis currently rely on use QT-prolonging agents. Using data from randomized controlled trial, TB-PRACTECAL, we investigated differences in QTcF among participants three interventional arms: BPaL (bedaquiline, pretomanid, and linezolid), BPaLC (BPaL with clofazimine), BPaLM moxifloxacin). Additionally, assessed whether age, body mass index, country were causally associated prolongation. The trial included South Africa,...
Compliance with treatment guidelines is essential to achieve successful outcomes in tuberculosis patients. Thus, we assessed if multidrug-resistant practices from 2012–2018 Uzbekistan were compliant national terms of regimens prescribed, weight-based drug dosages used, and documentation changes (such as prolongation intensive phase, change drugs, their reasons) the card Consilium form. A total 1481 patients included. Of them, only 25% received standardized per remaining individualized...
Tuberculosis (TB) and chronic hepatitis C virus infection (HCV) remain significant global health challenges, especially in low- middle-income countries. In Eastern Europe, a considerable percentage of multi-drug resistant (MDR) rifampicin (RR) TB populations show high HCV prevalence. Current WHO guidelines do not routinely advise testing during MDR-TB treatment, despite being risk factor for drug-induced liver complications patients. This study investigates the co-treatment MDR/RR-TB HCV,...
Tuberculosis (TB) is one of the ten leading causes death worldwide. The COVID-19 pandemic led to a reduction in outpatient and inpatient services due redistribution medical personnel increased laboratory research combat COVID-19, which affected solution problems phthisiology. aim study - assess impact on fight against TB Tashkent, Uzbekistan during period strict quarantine from March end 2020. included all adult patients with registered March-December 2019, 2020 2021. Data collected 1775...
Compliance with treatment guidelines is crucial for effective and successful of multidrug-resistant tuberculosis (MDR-TB). Thus, we assessed if MDR-TB practices in Uzbekistan from 2012-18 were compliant the national terms 1) prescription initial standard regimens, 2) correct weight-based drug 3) documentation changes (prolongation intensive phase regimen during both phases treatment). Data 1481 adult MDR TB patients analyzed. Overall, 25% treated using standardized regimens compliance...
Poor adherence tо drug-resistant tuberculosis (DR-TB) treatment is а well known public health problem worldwide. Exploration of factors associated with low DR-TB important for improving the care patients. The aim this study was to assess patients during intensive phase hospital by using validated eight-item Morisky Medication Adherence Scale (MMAS-8) and socio-demographic clinical adherence. A total 179 were included in study. This an analytical cross-sectional exploring period 2019-2020....