A5082735239- Spinal Cord Injury Research
- Advanced Neuroimaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- MRI in cancer diagnosis
- Cerebral Palsy and Movement Disorders
- Advanced Sensor and Energy Harvesting Materials
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Bone and Joint Diseases
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Conducting polymers and applications
- Pain Management and Treatment
- Cancer-related molecular mechanisms research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Circular RNAs in diseases
Tianjin Medical University General Hospital
2022-2025
China International Science and Technology Cooperation
2022-2025
University of Alberta
2023
Abstract Peripheral nerve injuries represent one of the most common causes permanent disabilities. Therapeutic electrical stimulation has been widely used in neural regeneration for decades. Combined with implantation a cuff, several outcomes have proven effectiveness and feasibility neuroprosthetic applications. However, current strategy fails to complete repair. There is lack research on long‐term implantable nanogenerators neurostimulation scenario. Especially considering many disease...
Abstract Background Inadequate nerve regeneration and an inhibitory local microenvironment are major obstacles to the repair of spinal cord injury (SCI). The activation differentiation fate regulation endogenous neural stem cells (NSCs) represent one most promising approaches. Metformin has been extensively studied for its antioxidative, anti-inflammatory, anti-aging, autophagy-regulating properties in central nervous system diseases. However, effects metformin on NSCs remains be elucidated....
Abstract Traumatic spinal cord injury result in considerable and lasting functional impairments, triggering complex inflammatory pathological events. Spinal scars, often metaphorically referred to as “fire barriers,” aim control the spread of neuroinflammation during acute phase but later hinder axon regeneration stages. Recent studies have enhanced our understanding immunomodulation, revealing that injury-associated inflammation involves various cell types molecules with positive negative...
Spinal cord injury poses considerable challenges, particularly in diaphragm paralysis. To address limitations existing pacing technologies, we report an implantable, self-driven system based on a microvibration triboelectric nanogenerator (MV-TENG). Leveraging the efficient MV-TENG, harvests micromechanical energy and converts this into pulses for phrenic nerve stimulation. In vitro tests confirm stable MV-TENG output, while subcutaneous implantation of device rats results constant amplitude...
As a commonly used physical intervention, electrical stimulation (ES) has been demonstrated to be effective in the treatment of central nervous system disorders. Currently, researchers are studying effects on individual neurons and neural networks, which dependent factors such as intensity, duration, location, neuronal properties. However, exact mechanism action remains unclear. In some cases, repeated or prolonged can lead changes morphology function neuron. this study, immunofluorescence...
Two previous oscillating-gradient-spin-echo (OGSE) studies of human acute ischemic stroke using different diffusion waveforms (40 Hz, one-period; 50 two-period) have reported considerably mean diffusivity (MD) changes in lesion white matter relative to long time (“0 Hz”) pulsed-gradient-spin-echo (PGSE). Here both OGSE were acquired 8 patients. Lesions showed marked dependencies with MD reduction 40% for PGSE compared 25% 40Hz, and yet 50Hz was only a bit less (21%). Large heterogeneity...
Motivation: The diffusion dispersion rate (DDR, slope of with frequency oscillating-gradient-spin-echo - OGSE) has been probed in animal stroke models and healthy human brain, but not explored acute ischemic stroke. Goal(s): Our goal is to map DDR explore its insight on the biophysical mechanisms related reduced Approach: maps using OGSE 25/40/50Hz were acquired 12 patients. Results: significantly higher lesions relative contralateral white matter, highest brain regions presumably larger...
Motivation: Can two different diffusion experiments (tensor-valued encoding and oscillating-gradient-spin-echo) support the role of axon beading for restriction in acute ischemic stroke?Goal(s): To evaluate whether tensor-valued yields an model that predicts experimental changes diffusivity measured with OGSE. Approach: Tensor-valued OGSE/PGSE MRI were same stroke patients. Monte Carlo simulations used to assess links between these independent measurements. Results: The derived predictions...
Abstract Purpose Tensor‐valued diffusion encoding can disentangle orientation dispersion and subvoxel anisotropy, potentially offering insight into microstructural changes after cerebral ischemia. The purpose was to evaluate tensor‐valued MRI in human acute ischemic stroke, assess potential confounders from time dependencies, compare Monte Carlo simulations of axon beading. Methods Linear (LTE) spherical (STE) b‐tensor with inherently different effective times were acquired 21 stroke...
Although plenty of evidences from preclinical studies have led to potential treatments for patients with spinal cord injury (SCI), the failure translate promising findings into clinical advances has long puzzled researchers. Thus, a more reliable combination anatomical assessment and behavioral testing is urgently needed improve translational worth studies. To address this issue, present study was designed relate magnetic resonance imaging (MRI)-based outcome in rat contusion model. Rats...
Short diffusion time oscillating gradient spin echo (OGSE) showed less water reduction in acute human stroke lesions (n=28) than the typical clinically used long pulsed (PGSE) method. The dependency is far greater ischemic lesions, particularly white matter, contralateral healthy brain. These effects were heterogeneous across lesion with larger OGSE-PGSE differences regions indicative of axons. range MD decrease patients as measured OGSE and PGSE a linear correlation consistent concomitant...