A5020817992- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Memory Processes and Influences
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Epilepsy research and treatment
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Child and Adolescent Psychosocial and Emotional Development
- Phosphodiesterase function and regulation
- Amino Acid Enzymes and Metabolism
- Pharmacological Effects and Assays
- Diverse academic and cultural studies
- Medicinal Plants and Neuroprotection
University of Buenos Aires
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2005-2020
Institute of Astronomy and Space Physics
2014
Institute for Medical Research
2014
Alzheimer's disease (AD) can be considered as a of memory in its initial clinical stages. Amyloid-β (Aβ) peptide accumulation is central to the initiation leading later intracellular neurofibrillary tangles (NFTs) cytoskeletal t
Sildenafil (1, 3, 10, and 30 mg/kg, intraperitoneally (i.p.)), a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor, facilitated retention performance of one-trial step-through inhibitor avoidance task, when administered to male Swiss mice immediately after training, as indicated by on test 48 h later. The dose-response curve was an inverted U in this dose range, although only the 3 mg/kg sildenafil produced significant effects. did not affect response...
Although it is generally accepted that memory consolidation requires regulation of gene expression, only a few transcription factors (TFs) have been clearly demonstrated to be specifically involved in this process. Increasing research data point the participation Rel/nuclear factor-kappaB (NF-kappaB) family TFs and neural plasticity. Here we found two independent inhibitors NF-kappaB induced impairment one-trial step-through inhibitory avoidance paradigm mice: post-training administration...
CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, first test was performed and hemicholinium (HC-3, 1.0 μg/mice), specific inhibitor high-affinity choline uptake brain cholinergic neurons, given intracerebroventricularly immediately after. Twenty four hours treatment, tested during five consecutive days, each 24 h apart. Retention...
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to understanding of the complex processes memory consolidation reconsolidation. We discuss post-training (memory consolidation) post-reactivation reconsolidation) effects icv infusions hemicholinium, a central inhibitor acetylcholine synthesis, intraperitoneal administration L-NAME, non-specific nitric oxide synthase, intrahippocampal injections an...