A5072617874- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Karst Systems and Hydrogeology
- Groundwater and Watershed Analysis
- Groundwater and Isotope Geochemistry
- RNA Research and Splicing
University of Chinese Academy of Sciences
2024
Shanghai Institute of Nutrition and Health
2024
China University of Geosciences
2006
Abstract Non-coding variants associated with complex traits can alter the motifs of transcription factor (TF)–deoxyribonucleic acid binding. Although many computational models have been developed to predict effects non-coding on TF binding, their predictive power lacks systematic evaluation. Here we evaluated 14 different built position weight matrices (PWMs), support vector machines, ordinary least squares and deep neural networks (DNNs), using large-scale in vitro (i.e. SNP-SELEX) vivo...