About
Contact & Profiles
A5048722764
Research Areas
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
Indiana University – Purdue University Indianapolis
2021-2024
BACKGROUND: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about role deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin carboxyl-terminal hydrolase 1), a deubiquitinase, has been shown to reduce AKT1 (AKT serine/threonine kinase 1) degradation, resulting higher levels. Given that pathological hypertension, we hypothesized deficiency attenuates PAH by means reductions AKT1. METHODS:...
10.1161/circulationaha.123.065304
article
EN
mit
Circulation
2024-05-02
10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1070
article
EN
2021-05-01
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