A5084097017- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- Crystallography and molecular interactions
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Advancements in Photolithography Techniques
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Nanofabrication and Lithography Techniques
- Synthesis of Organic Compounds
- Microfluidic and Capillary Electrophoresis Applications
- Enzyme Structure and Function
- 14-3-3 protein interactions
- Mass Spectrometry Techniques and Applications
- Alzheimer's disease research and treatments
Meiji Pharmaceutical University
2013-2023
Tohoku Medical and Pharmaceutical University
2018
Komatsu (Japan)
2018
Sendai University
2018
In connection with our studies of biologically active 1,2,3,4-tetrahydroisoquinoline marine natural products, we describe herein a useful intramolecular photoredox transformation 7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione tricyclic models into 5-hydroxy-tetrahydroisoquinol[1,3]dioxoles in excellent yields. We applied this methodology to the renieramycin M renieramycins T and S saframycin A. The results cytotoxicity are also presented.
In this study, we report on the direct confirmation of crystal structure and conformation API in tablets by 3D ED/MicroED. Allegra, Clarith, Ibrance were selected for study. The structures conformations analyzed detail to determine whether there any changes polymorphism crystals during formulation process. As a result, it was confirmed that polymorphs Allegra (fexofenadine hydrochloride, Form I) Clarith (clarithromycin, II) unchanged. These results directly confirm has been no change process...
Nakijinols A, B and analogues E through G, which are structurally unique biologically significant sesquiterpenoid benzoxazoles, can be efficiently obtained in a highly unified manner from the quinone, smenospongine. The starting material is accessible (+)-5-methyl Wieland-Miescher ketone. synthetic method features strategic construction of requisite dihydroxylated benzoxazole substructure via ring closure N-(2-hydroxyphenyl)-formamide or -acetamide moiety. synthesis nakijinols reported here...
In this study, we elucidate the crystal structures of three pharmaceuticals using only three-dimensional (3D) ED/MicroED, thereby unambiguously determining whether they were salts or cocrystals based on hydrogen position identification. The analysis targets in study indomethacin nicotinamide cocrystals, ensitrelvir fumaric acid and bisoprolol hemifumarate Form I. 3D ED/MicroED revealed that all crystals had residual electron density key segments, which could be clearly identified as atoms,...
Tricyclic lactam model compounds of the left half (ABC ring) renieramycin and saframycin anticancer natural products were prepared from common intermediate 6a. Readily available alcohol 6a was converted into enamide 8, this followed by transformation 6b through a hydrobromination reaction in stereoselective manner. Some diastereomers at C-6 to C-11a tricyclic having several functional groups or good yields. We presented also an unexpected reductive acetylation p-quinone produce corresponding...
Alzheimer's disease (AD) causes cognitive impairment in the elderly and is a severe problem worldwide. One of major reasons for pathogenesis AD thought to be due accumulation amyloid beta (Aβ) peptides that result neuronal cell death brain. In this study, bioassay-guided fractionation was performed develop seed compounds anti-AD drugs can act as dual inhibitors BACE1 Aβ aggregation from secondary metabolites produced by Streptomyces sp. To improve solubility, crude extracts were methylated...