About
Contact & Profiles
A5115012421
Research Areas
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
University of California, San Francisco
2024
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4 + T with synthetic Notch (synNotch) receptors driving antigen-triggered production anti-inflammatory payloads. Screening diverse library suppression programs, observed the strongest cytotoxic cell attack by both factors (interleukin-10, transforming growth factor–β1, programmed death ligand 1) sinks proinflammatory...
10.1126/science.adl4793
article
EN
Science
2024-12-05
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