A5103277214- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Antifungal resistance and susceptibility
- Analytical Chemistry and Chromatography
- Essential Oils and Antimicrobial Activity
- Cancer, Hypoxia, and Metabolism
- Polyamine Metabolism and Applications
- Advanced oxidation water treatment
- Pesticide Residue Analysis and Safety
- Analytical Methods in Pharmaceuticals
- Biochemical and Molecular Research
- Advanced Photocatalysis Techniques
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Water Treatment and Disinfection
- Plant responses to water stress
- Metabolism, Diabetes, and Cancer
- Forensic Toxicology and Drug Analysis
- Medicinal Plants and Neuroprotection
- Antibiotics Pharmacokinetics and Efficacy
- Environmental remediation with nanomaterials
- Pharmacogenetics and Drug Metabolism
- Date Palm Research Studies
University of Sharjah
2018-2024
Universidade Nova de Lisboa
2024
Rede de Química e Tecnologia
2024
United Arab Emirates University
2016-2019
Al Ain Hospital
2016
The present study highlights the influence and efficacy of a self-doped carbon (C)–ZnO/TiO2 hybrid heterojunction for photocatalytic degradation ofloxacin (OFX) in aqueous media. flower-like was prepared via hydrothermal treatment at varying concentrations ZnO TiO2. C doping internally introduced to lattice by decomposition polyvinylpyrrolidone as source achieve better band alignment. A systematic investigation performed elucidate mechanism photodegradation analyzing parameters such...
The biochemical composition, secondary metabolites (phenolic compounds, flavonoids) and antimicrobial potential of different varieties Emirati date (Phoenix dactylifera L.) pits were investigated. Total phenolic acids (TPC) total flavonoid contents (TFC) the measured using a Folin-Ciocalteau reagent. Different organic solvents [(n-hexane; H2O: EtOH (1:1); ethyl acetate; acetone: Water methanol: Chloroform (1:1)] compared to evaluate phytotoxicity Ajwa, Fard, Khalas, Khodari, Abu Maan, Lulu,...
Metabolic syndrome (MetS) is a disorder characterized by group of factors that can increase the risk chronic diseases, including cardiovascular diseases and type 2 diabetes mellitus (T2D). Metabolomics has provided new insight into disease diagnosis biomarker identification. This cross-sectional investigation used an untargeted metabolomics-based technique to uncover metabolomic alterations their relationship pathways in normoglycemic prediabetic MetS participants improve diagnosis. Plasma...
Trastuzumab and tamoxifen are two of the most widely prescribed anti-cancer drugs for breast cancer (BC). To date, few studies have explored impact anticancer on metabolic pathways in BC. Metabolomics is an emerging technology that can identify new biomarkers tracking therapy response novel therapeutic targets.We employed ultra-high-performance liquid chromatography-quadrupole time flight mass spectrometry (UHPLC-QTOF-MS) to investigate changes MCF-7 SkBr3 cell lines treated with either...
The occurrence and persistence of pharmaceuticals in the food chain, particularly edible crops, can adversely affect human environmental health. In this study, impacts absorption, translocation, accumulation, degradation paracetamol different organs leafy vegetable crop spinach (Spinacia oleracea) were assessed under controlled laboratory conditions. Spinach plants exposed to 50 mg/L, 100 200 mg/L 20% Hoagland solution at vegetative phase a hydroponic system. Exposed exhibited pronounced...
The extracts of E. alte offer promising potential as renewable resources for various chemical derivative products aimed at addressing antibiotic resistance. These exhibited significant activity against methicillin-resistant Staphylococcus aureus (MRSA), a strain known its resistance to multiple antibiotics. were found be effective several common antibiotics, including Imipenem, Ampicillin, Penicillin G, Oxacillin, and Amoxicillin-clavulanate. GC-MS analysis revealed that the...
Road dust is a major source of pollution in the environment, carrying different pollutants, including heavy metals and metalloids, from one location to another. This study assesses concentrations eight metalloid (Zn, Pb, Mn, Fe, Cr, Cu, Cd, Ni, As) samples collected sixty-eight streets Sharjah, United Arab Emirates using ICP-OES, as well investigates their effects on both environment humans. Mean elements μg/g across sites were 392 ± 46 (Zn), 68.28 11.3 (Pb), 1437 67 (Mn), 39,481 4611 (Fe),...
Hepatocellular carcinoma (HCC) is the second prominent cause of cancer-associated death worldwide. Usually, HCC diagnosed in advanced stages, wherein sorafenib, a multiple target tyrosine kinase inhibitor, used as first line treatment. Unfortunately, resistance to sorafenib usually encountered within six months Therefore, there critical need identify underlying reasons for drug resistance. In present study, we investigated proteomic and metabolomics alterations accompanying hepatocellular...
In cancer therapy, exosomes efflux enhances resistance of cells toward anticancer agents through mediating the transport drugs outside cells. this study, a rapid, simple and highly sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed validated for determination Doxorubicin (DOX) in human plasma using Ketotifen as an internal standard (IS). Plasma samples spiked with DOX two cell lines (A549 & MCF-7) were incubated different...
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or hormonal replacement therapy postmenopausal have long been associated with an increased risk yeast infections. Nevertheless, the effect underlying role E2 Candida albicans infections is not well understood. To address this issue, functional, transcriptomic, and metabolomic analyses were performed on C. cells subjected temperature serum induction presence absence E2. filament formation was observed treated cells....
The presence and fate of contaminants emerging concern (CECs) in wastewater have received growing attention due to their potential impacts on human health the environment. In this study, authors assessed CECs influent effluent Sharjah treatment plant (SWWTP), a conventional activated sludge system, over 1 year period. is capital city Emirate UAE. Characterisation required development elaborate analytical techniques for detection quantification at nanogram per litre level. A total 57 were...
A sensitive and selective method for detection quantitation of the enantiomers 18 synthetic cathinones with tertiary amine structure using HPLC–UV-VIS has been developed. Two chiral columns, Astec Cellulose DMP Amylose-based Chiralpak AS-H, have examined separately. Mobile phase composed hexane, isopropanol triethylamine (99.0:1.0:0.1) was used under an isocratic elution mode. Three these compounds were separated simultaneously after being spiked into urine plasma samples. 2,3-Methylenedioxy...
A simple, fast and highly sensitive RP-UPLC-MS/MS method was developed validated for the simultaneous determination of sofosbuvir (SR) its metabolite GS331007 in human plasma using ketotifen as an internal standard (IS). The separation achieved on Acquity UPLC BEH C18 (50 × 2.1 mm, i.d. 1.7 µm, Waters, USA) column acetonitrile:5 mM ammonium formate:0.1% formic acid (85:15:0.1% v/v/v) a mobile phase at flow rate 0.35 mL/min isocratic elution. Xevo TQD UPLC-MS/MS operated under...
The present work describes the optimization and validation of a highly selective sensitive analytical method using solid phase extraction liquid chromatography tandem mass spectrometry (SPE LC-MS/MS) for determination some frequently prescribed pharmaceuticals in urban wastewater received treated by Sharjah sewage treatment plant (STP). efficiency different SPE cartridges was tested simultaneous successfully accomplished hydrophilic-lipophilic-balanced reversed Waters® Oasis HLB...
Candida albicans is the leading cause of life-threatening bloodstream candidiasis, especially among immunocompromised patients. The reversible morphological transition from yeast to hyphal filaments in response host environmental cues facilitates C. tissue invasion, immune evasion, and dissemination. Hence, it widely considered that filamentation represents one major virulence properties albicans. We have previously characterized Ppg1, a PP2A-type protein phosphatase controls filament...
Sensitive spectrofluorometric and HPLC with fluorescence detection methods have been developed for determination of <italic>para</italic>-aminohippuric acid (a marker used estimating effective renal plasma flow) in the presence β-cyclodextrin.
Metabolic profiling of cancer cells can play a vital role in revealing the molecular bases development and progression. In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for determination signatures found ER+/PR+ breast derived from MCF-7 using different extraction solvents including: A, formic acid water; B, ammonium hydroxide C, ethyl acetate; D, methanol: water (1:1, v/v); E, acetonitrile: v/v). The greatest rate diversity metabolites occurs A E....
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Children’s health and safety may be compromised if exposed to metals through contaminated toys. Hence, evaluation of the quality toys available in markets is essential protect children. This study undertaken identify presence contents plastic compares results with national international limits. For this purpose, 56 types popular children’s marked were purchased from UAE metal estimated 156 toy samples by inductively coupled plasma-optical emission spectrometry (ICP-OES) technique. The reveal...